Spirostanol pentaglycosides from the underground parts of polianthestuberosa

  • J Nat Prod. 2002 Oct;65(10):1424-8. doi: 10.1021/np020133t.
Yoshihiro Mimaki  1 ,  Akihito Yokosuka ,  Chiseko Sakuma ,  Hiroshi Sakagami ,  Yutaka Sashida
Affiliations
  • 1. School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Japan. [email protected]
PMID: 12398537 DOI: 10.1021/np020133t
Abstract

Phytochemical analysis of the underground parts of Polianthes tuberosa has resulted in the isolation of four new spirostanol saponins with five Monosaccharides (1-4). Their structures were determined by spectroscopic analysis, including extensive 1D and 2D NMR data, and the results of hydrolytic cleavage. The cytotoxic activities of 1-4 against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells are reported.