1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

  • J Med Chem. 2005 May 5;48(9):3428-32. doi: 10.1021/jm049121q.
Mariangela Biava  1 ,  Giulio Cesare Porretta ,  Andrea Cappelli ,  Salvatore Vomero ,  Fabrizio Manetti ,  Maurizio Botta ,  Lidia Sautebin ,  Antonietta Rossi ,  Francesco Makovec ,  Maurizio Anzini
Affiliations
  • 1. Dipartimento di Studi di Chimica e Tecnolgia delle Sostanze Biologicamente Attive, Università "La Sapienza", P.le A. Moro 5, I-00185 Roma, Italy. [email protected]
PMID: 15857149 DOI: 10.1021/jm049121q
Abstract

A small set of substituted 1,5-diarylpyrrole-3-acetic and -glyoxylic acid derivatives have been synthesized, and their cyclooxygenase (COX-1 and COX-2) inhibiting properties have been evaluated. Some compounds proved to be highly selective COX-2 inhibitors, and their affinity data have been rationalized through docking simulations in terms of interactions with a crystallographic model of the COX-2 binding site.