Lignans from Kadsura angustifolia

  • J Nat Prod. 2008 Apr;71(4):558-63. doi: 10.1021/np0705108.
Xue-Mei Gao  1 ,  Jian-Xin Pu ,  Sheng-Xiong Huang ,  Liu-Meng Yang ,  Hao Huang ,  Wei-Lie Xiao ,  Yong-Tang Zheng ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 18278869 DOI: 10.1021/np0705108
Abstract

Phytochemical investigation of Kadsura angustifolia led to the isolation and identification of 26 Lignans and two triterpenoids, including 11 new Lignans named kadangustins A-K ( 1- 11). The structures and stereochemistry of 1- 11 were elucidated by analysis of spectroscopic data. Except for 11 and 20, all the Lignans were evaluated for their inhibitory activity against HIV-1. Binankadsurin A ( 19) showed anti-HIV activity with an EC 50 value of 3.86 microM.

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