Lignans with anti-HIV activity from Schisandra propinqua var. sinensis

  • J Nat Prod. 2009 Jun;72(6):1133-41. doi: 10.1021/np900123z.
Xiao-Nian Li  1 ,  Jian-Xin Pu ,  Xue Du ,  Liu-Meng Yang ,  Hui-Mei An ,  Chun Lei ,  Fei He ,  Xiao Luo ,  Yong-Tang Zheng ,  Yang Lu ,  Wei-Lie Xiao ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
PMID: 19413342 DOI: 10.1021/np900123z
Abstract

Fourteen new Lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.