Caffeic acid esters and lignans from Piper sanguineispicum

  • J Nat Prod. 2010 Nov 29;73(11):1884-90. doi: 10.1021/np1005357.
Billy Joel Cabanillas  1 ,  Anne-Cécile Le Lamer ,  Denis Castillo ,  Jorge Arevalo ,  Rosario Rojas ,  Guillaume Odonne ,  Geneviève Bourdy ,  Béatrice Moukarzel ,  Michel Sauvain ,  Nicolas Fabre
Affiliations
  • 1. Université de Toulouse, UPS, UMR 152 (Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox), F-31062 Toulouse Cedex 9, France.
PMID: 20954722 DOI: 10.1021/np1005357
Abstract

Three new caffeic acid esters (1-3), four new Lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC(50) 2.0 and 1.8 μM, respectively) with moderate cytotoxicity on murine macrophages.