Overcoming resistance to β-lactam antibiotics

β-Lactam Antibiotics are one of the most important Antibiotic classes but are plagued by problems of resistance, and the development of new β-lactam Antibiotics through side-chain modification of existing β-lactam classes is not keeping pace with resistance development. In this JOCSynopsis, we summarize small molecule strategies to overcome resistance to β-lactam Antibiotics. These approaches include the development of β-lactamase inhibitors and compounds that interfere with the ability of the bacteria to sense an Antibiotic threat and activate their resistance mechanisms.