Biological activities of triterpenoids from Poraqueiba sericea stems

  • Nat Prod Res. 2017 Jun;31(11):1333-1338. doi: 10.1080/14786419.2016.1241998.
Ilhem Zebiri  1 ,  Mohamed Haddad  2 ,  Laurent Duca  3 ,  Michel Sauvain  2 ,  Lucie Paloque  4  5 ,  Billy Cabanillas  6 ,  Elsa Rengifo  6 ,  Jean-Bernard Behr  1 ,  Laurence Voutquenne-Nazabadioko  1
Affiliations
  • 1. a Institut de Chimie Moléculaire de Reims UMR 7312 CNRS , Université de Reims , Reims , France.
  • 2. b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
  • 3. c Unité Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UMR CNRS 7369 , Université de Reims , Reims , France.
  • 4. d CNRS , LCC (Laboratoire de Chimie de Coordination) , Toulouse , France.
  • 5. e Université de Toulouse, UPS, INPT , Toulouse , France.
  • 6. f Instituto de Investigaciones de la Amazonía Peruana (IIAP) , Iquitos , Perú.
PMID: 27736194 DOI: 10.1080/14786419.2016.1241998
Abstract

Eleven compounds were isolated from Poraqueiba sericea stems and identified as niga-ichigoside-F1 (1), trachelosperoside B1 (2), 4-epi-niga-ichigoside (7), 19α-hydroxyasiatic acid (3), myrianthic acid (4), hyptatic acid (5), trachelosperogenin B (6), arjunolic acid (8), and trachelosperogenin E (9), secologanoside (10) and secoxyloganin (11). Compounds 1-11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1-6 and 8-11 were tested for their cytotoxic activities on fibroblasts, 1-3, 5-6, 8-11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and 1-2, 5 and 7-10 were tested using bioautography for their β-glucosidase. No antileishmanial activity was detected; compounds 1, 2 and 11 showed a moderate cytotoxic activity with IC50 17.7, 20.5 and 10.9 μg/mL, respectively; compounds 2, 8, 9 and 10 gave a percentage of inhibition ranging from 13 to 16% (at 50 μg/mL) and compounds 1 and 2 showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays.

Keywords
Icacinaceae; Poraqueiba sericea; secoiridoids; triterpenes.
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