A new indole alkaloid from the traditional Chinese medicine Chansu

  • J Asian Nat Prod Res. 2018 Jun;20(6):581-585. doi: 10.1080/10286020.2017.1339697.
Ying-Hui Dai  1 ,  An-Dong Wang  1 ,  Yu-Lin Chen  1 ,  Ming-Yu Xia  2 ,  Xin-Yi Shao  1 ,  Dong-Chun Liu  1 ,  Dong Wang  1
Affiliations
  • 1. a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • 2. b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang 110016 , China.
PMID: 28625094 DOI: 10.1080/10286020.2017.1339697
Abstract

A new indole alkaloid N'-formylserotonin (1), along with five known Indole Alkaloids N'-methylserotonin (2), 5-hydroxy-1H-indole-3-carbaldehyde (3), N-acetylserotonin (4), 6-hydroxy-1-oxo-3,4-dihydro-β-carboline (5), and bufoserotoin C (6), were isolated from the water extract of traditional Chinese medicine Chansu. Their structures were elucidated on the basis of spectral analyses. The cytotoxicities of 1-6 against human lung adenocarcinoma epithelial cells A549 were tested using the MTT method. Compound 6 exhibited stronger cytotoxic effect than 5-FU, and 1-5 showed no cytotoxic effects. Bufoserotonin C is one of the cytotoxic components in water-soluble extract of Chansu.

Keywords
Chansu; N′-formylserotonin; Toad venom; bufoserotonin C; cytotoxic activity.
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