Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana

  • J Nat Prod. 2017 Dec 22;80(12):3211-3217. doi: 10.1021/acs.jnatprod.7b00587.
Luke P Robertson  1  2 ,  Sandra Duffy  2 ,  Yun Wang  3 ,  Dongdong Wang  2 ,  Vicky M Avery  2 ,  Anthony R Carroll  1  2  3
Affiliations
  • 1. Environmental Futures Research Institute, Griffith University , Southport 4222, Gold Coast, Australia.
  • 2. Griffith Institute for Drug Discovery, Griffith University , Nathan 4111, Brisbane, Australia.
  • 3. Centre for Clean Environment and Energy, Griffith University , Southport 4222, Gold Coast, Australia.
PMID: 29236492 DOI: 10.1021/acs.jnatprod.7b00587
Abstract

Three members of a new class of ascorbic acid-adduct Indole Alkaloids (1-3), a new prenylated indole alkaloid (4), and five known compounds (5-9) were isolated from the leaves of Flindersia pimenteliana. The structures of 1-4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC50 values ranging from 0.19 to 3.6 μM.