A new flavonoid from the leaves of Atalantia monophylla (L.) DC

  • Nat Prod Res. 2019 Apr;33(8):1115-1121. doi: 10.1080/14786419.2018.1457667.
Priyapan Posri  1 ,  Jittra Suthiwong  1 ,  Pitchayakarn Takomthong  2 ,  Chatchawan Wongsa  1 ,  Chindawadee Chuenban  1 ,  Chantana Boonyarat  2 ,  Chavi Yenjai  1
Affiliations
  • 1. a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
  • 2. b Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand.
PMID: 29600742 DOI: 10.1080/14786419.2018.1457667
Abstract

A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4'-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer's disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman's method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.

Keywords
acetylcholine esterase; antioxidant; flavonoid.
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