Nitric oxide inhibitory coumarins from the roots and rhizomes of Notopterygium incisum

  • Fitoterapia. 2018 Nov;131:65-72. doi: 10.1016/j.fitote.2018.10.002.
Xikang Zheng  1 ,  Yuemei Chen  1 ,  Xiaoli Ma  1 ,  Chen Zhang  1 ,  Zhengren Xu  1 ,  Yong Jiang  1 ,  Pengfei Tu  2
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • 2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: [email protected].
PMID: 30291965 DOI: 10.1016/j.fitote.2018.10.002
Abstract

Phytochemical study on the roots and rhizomes of Notopterygium incisum resulted in the isolation of six new Coumarins, notoptetherins A - F (1-6), and 20 known analogues (7-26). Their structures were elucidated on the basis of extensive analyses of NMR and HRMS data, and the absolute configurations of 5 and 6 were established by Mo2(AcO)4-induced CD and exciton chirality, respectively. Moreover, a biomimetic synthesis of 6 from 21 was employed to confirm its absolute configuration. In a subsequent activity screening, compounds 12 and 17 exhibited potent inhibition against LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values of 12.7 and 10.2 μM, respectively.

Keywords
Coumarins; Nitric oxide; Notopterygium incisum.
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