Targeting laryngeal cancer cells with 5-fluorouracil and curcumin using mesoporous silica nanoparticles
- Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820962114. doi: 10.1177/1533033820962114.
- 1. Department of Otolaryngology, Head and Neck Surgery, the Second Hospital, 12510Jilin University, Changchun, Jilin, People's Republic of China.
- 2. Department of Pathophysiology, College of Basic Medical Science, 12510Jilin University, Changchun, Jilin, People's Republic of China.
Objective: To explore the inhibitory and synergistic effects of 5-fluorouracil and curcumin on Hep-2 laryngeal Cancer cells and clarify the effect of mesoporous silica nanoparticles as drug carriers.
Methods: The inhibitory effects of 5-fluorouracil and curcumin on Hep-2 cells were detected using the CCK-8 assay. CompuSyn was used to calculate the synergistic effect of the 2 drugs. Flow cytometry was used to detect Apoptosis and cell cycle arrest induced by 5-fluorouracil and curcumin. The drugs were loaded into mesoporous nanoparticles. Western blotting was used to detect the expression of related proteins after treatment. The growth of subcutaneous tumors in BALB/c nude after the intraperitoneal injection with drug-loaded mesoporous silica nanoparticles was recorded.
Results: 5-Fluorouracil and curcumin synergistically induced Apoptosis and cell cycle arrest in Hep-2 cells. Mesoporous silica nanoparticles as drug carriers enhanced the therapeutic effects of 5-fluorouracil and curcumin.
Conclusions: Mesoporous silica nanoparticles are expected to be effective drug carriers that enhance the synergistic effects of 5-fluorouracil and curcumin on laryngeal Cancer.
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Research Areas: Cancer
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