Zwitterionic polymer modified xanthan gum with collagen II-binding capability for lubrication improvement and ROS scavenging

  • Carbohydr Polym. 2021 Nov 15:274:118672. doi: 10.1016/j.carbpol.2021.118672.
Kai Ren  1 ,  Xiang Ke  1 ,  Zhu Chen  1 ,  Yao Zhao  1 ,  Lu He  1 ,  Peng Yu  1 ,  Jiaqi Xing  1 ,  Jun Luo  1 ,  Jing Xie  2 ,  Jianshu Li  3
Affiliations
  • 1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, PR China.
  • 2. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, PR China. Electronic address: [email protected].
  • 3. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Med-X Center for Materials, Sichuan University, Chengdu 610041, PR China. Electronic address: [email protected].
PMID: 34702446 DOI: 10.1016/j.carbpol.2021.118672
Abstract

High friction of damaged cartilage requires long-acting lubricated additive, which can also effectively scavenge reactive oxidative species (ROS) produced by mechanically stimulated chondrocytes. In this study, xanthan gum (XG) was grafted by poly (sulfobetaine methacrylate) (PSBMA) (the [XG]/[SBMA] molar ratio is 1:5 or 1:10), forming nanoparticles and then conjugated with Collagen II-binding peptide, finally obtaining CBPXGSB1/5 or CBPXGSB1/10. Therein, the CBPXGSB1/5 was chosen as optimal lubricated additive. The results show that hydrated effect of PSBMA side chains endows CBPXGSB1/5 with favorable lubrication property (COF is 0.063). Furthermore, the CBPXGSB1/5 combining lubrication property and specific binding capability together may achieve the long-acting lubrication for injured cartilage in medical field. The CBPXGSB1/5 also possesses antioxidation verified by DPPH assay and exhibits synergistically enhanced ROS (OH, O2- and H2O2) scavenging. Besides, cytotoxicity experiment demonstrates that CBPXGSB1/5 has good biocompatibility. Therefore, multifunctional CBPXGSB1/5 developed here may have promising application potential in osteoarthritis treatment.

Keywords
Collagen II binding; Lubrication; Polyzwitterion; ROS scavenging; Xanthan gum.
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