7-Methylguanine Inhibits Colon Cancer Growth in Vivo

  • Acta Naturae. 2024 Apr-Jun;16(2):50-52. doi: 10.32607/actanaturae.27422.
K I Kirsanov  1  2 ,  T I Fetisov  1 ,  E E Antoshina  1 ,  T G Gor'kova  1 ,  L S Trukhanova  1 ,  S I Shram  3 ,  I Yu Nagaev  3 ,  Yu A Zolotarev  3 ,  L Abo Qoura  1  2 ,  V S Pokrovsky  1  2 ,  M G Yakubovskaya  1 ,  V K Švedas  4  5 ,  D K Nilov  4
Affiliations
  • 1. Blokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
  • 2. RUDN University, Medical Institute, Moscow, 117198 Russian Federation.
  • 3. National Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
  • 4. Lomonosov Moscow State University, Belozersky Institute of Physicochemical Biology, Moscow, 119991 Russian Federation.
  • 5. Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119234 Russian Federation.
PMID: 39188268 DOI: 10.32607/actanaturae.27422
Abstract

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of Cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.

Keywords
BALB/c mice; colon cancer; inhibitor; methylguanine; poly(ADP-ribose) polymerase 1; tRNA-guanine transglycosylase.
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