Zinc oxide nanoparticles promote migrasomes formation

  • J Hazard Mater. 2025 Jun 15:490:137792. doi: 10.1016/j.jhazmat.2025.137792.
Ang Li  1 ,  Chengxiong Yang  2 ,  Leiliang Zhang  3
Affiliations
  • 1. Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China; School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China; Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
  • 2. School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. Electronic address: [email protected].
  • 3. Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China; Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. Electronic address: [email protected].
PMID: 40048781 DOI: 10.1016/j.jhazmat.2025.137792
Abstract

The rising pollution from zinc oxide nanoparticles (ZnO-NPs) poses significant global concerns due to their widespread environmental presence and potential negative effects on human health. This study explores how ZnO-NPs impact migrasomes formation, a crucial process for cellular migration and communication. Our findings indicate that 28 nm ZnO-NPs enhance migrasomes formation, correlating with increased levels of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and GTP-RhoA-essential molecules in migrasomes biogenesis. Additionally, ZnO-NPs help alleviate mitochondrial damage caused by carbonyl cyanide 3-chlorophenylhydrazone (CCCP) through mitocytosis, which removes dysfunctional mitochondria, thereby preserving cellular integrity. The migrasomes induced by ZnO-NPs were found to contain various cellular components, including mitochondria, lysosomes, lipid droplets, and the ZnO-NPs themselves. These results underscore the role of ZnO-NPs in promoting migrasomes formation and protecting mitochondrial function, revealing significant implications for cellular behavior, therapeutic applications, and environmental and health safety.

Keywords
Lysosome; Migrasomes; Mitochondrion; PI(4,5)P2; ZnO-NPs.
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