2-5A is an immunotransmitter that fuels RNase L immunity

  • Immunity. 2025 Apr 8;58(4):770-772. doi: 10.1016/j.immuni.2025.03.007.
Songnan Wang  1 ,  Lingyin Li  2
Affiliations
  • 1. Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA.
  • 2. Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA. Electronic address: [email protected].
PMID: 40203803 DOI: 10.1016/j.immuni.2025.03.007
Abstract

cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fide immunotransmitter.

Products