RG7388 inhibits SFTSV replication by suppressing MDM2-mediated p53 degradation and preventing apoptosome disruption

  • Sci Bull (Beijing). 2026 Jan 15;71(1):55-59. doi: 10.1016/j.scib.2025.06.028.
Zixiang Liu  1 ,  Mengqian Huang  1 ,  Yuyang Liu  1 ,  Luna Cui  1 ,  Xixi Shi  1 ,  Honghua Chen  1 ,  Xiaoning Gao  1 ,  Zining Wang  1 ,  Qinting Lin  1 ,  Zhiyun Wang  2 ,  Yue Teng  3 ,  Tao Wang  4
Affiliations
  • 1. School of Life Sciences, Tianjin University, Tianjin 300072, China.
  • 2. School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. Electronic address: [email protected].
  • 3. State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China. Electronic address: [email protected].
  • 4. School of Life Sciences, Tianjin University, Tianjin 300072, China; State Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China. Electronic address: [email protected].
PMID: 40619297 DOI: 10.1016/j.scib.2025.06.028
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