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  4. Idasanutlin-d3-1

Idasanutlin-d3-1  (Synonyms: RG7388-d3-1)

Cat. No.: HY-153939S Purity: 98.31%
COA Handling Instructions

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Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia.

For research use only. We do not sell to patients.

Idasanutlin-d<sub>3</sub>-1 Chemical Structure

Idasanutlin-d3-1 Chemical Structure

Size Price Stock Quantity
1 mg USD 720 In-stock
5 mg USD 1800 In-stock
10 mg USD 2950 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Idasanutlin-d3-1:

Idasanutlin-d3-1 Related Antibodies

Top Publications Citing Use of Products

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Description

Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Idasanutlin-d3-1 Related Antibodies
Molecular Weight

619.50

Formula

C31H26D3Cl2F2N3O4
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(OC([2H])([2H])[2H])C=C(C(O)=O)C=C1)[C@H](N[C@H]2CC(C)(C)C)[C@H](C3=CC=CC(Cl)=C3F)[C@@]2(C#N)C4=CC=C(Cl)C=C4F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6142 mL 8.0710 mL 16.1420 mL
5 mM 0.3228 mL 1.6142 mL 3.2284 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.31%

COA (263 KB) HNMR (144 KB) RP-HPLC (248 KB) LCMS (113 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6142 mL 8.0710 mL 16.1421 mL 40.3551 mL
5 mM 0.3228 mL 1.6142 mL 3.2284 mL 8.0710 mL
10 mM 0.1614 mL 0.8071 mL 1.6142 mL 4.0355 mL
15 mM 0.1076 mL 0.5381 mL 1.0761 mL 2.6903 mL
20 mM 0.0807 mL 0.4036 mL 0.8071 mL 2.0178 mL
25 mM 0.0646 mL 0.3228 mL 0.6457 mL 1.6142 mL
30 mM 0.0538 mL 0.2690 mL 0.5381 mL 1.3452 mL
40 mM 0.0404 mL 0.2018 mL 0.4036 mL 1.0089 mL
50 mM 0.0323 mL 0.1614 mL 0.3228 mL 0.8071 mL
60 mM 0.0269 mL 0.1345 mL 0.2690 mL 0.6726 mL
80 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5044 mL
100 mM 0.0161 mL 0.0807 mL 0.1614 mL 0.4036 mL
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Idasanutlin-d3-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idasanutlin-d3-1RG7388-d3-1Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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