Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior

  • J Nat Prod. 1996 Nov;59(11):1066-8. doi: 10.1021/np9601667.
D F Chen  1 ,  S X Zhang ,  K Chen ,  B N Zhou ,  P Wang ,  L M Cosentino ,  K H Lee
Affiliations
  • 1. Department of Pharmacognosy, School of Pharmacy, Shanghai Medical University, People's Republic of China.
PMID: 8946749 DOI: 10.1021/np9601667
Abstract

Two new Lignans, interiotherins A (1) and B (2), along with two known Lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data. Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5 micrograms/mL, respectively.

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