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Cat. No.: HY-W746425

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Rapamycin dialdehyde

Rapamycin dialdehyde is a non-immunosuppressive macrolide dialdehyde that promotes neuronal regeneration and functional recovery by inducing neurite outgrowth, and inhibits solid tumor cell growth and hyperproliferative vascular diseases. Rapamycin dialdehyde is used in the research of neurodegenerative diseases and cancer.

For research use only. We do not sell to patients.

CAS No.: 500733-49-3
Formula: C₅₁H₇₉NO₁₅
Molecular Weight:946.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rapamycin dialdehyde Chemical Structure

CAS No.: 500733-49-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
3T3	IC50	0.72 μg/mL	Antineoplastic activity against mouse 3T3 ovarian tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against mouse 3T3 ovarian tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
3T3	IC50	0.68 μg/mL	Antineoplastic activity against mouse 3T3/H2N ovarian tumor cells resistant to cis-platin assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against mouse 3T3/H2N ovarian tumor cells resistant to cis-platin assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
A-431	IC50	0.91 μg/mL	Antineoplastic activity against human A431 vulva epidermoid tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human A431 vulva epidermoid tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
SK-BR-3	IC50	0.52 μg/mL	Antineoplastic activity against human SKBR3 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human SKBR3 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
MDA-MB-435	IC50	1.23 μg/mL	Antineoplastic activity against human MDA-435 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human MDA-435 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
SW-620	IC50	1.41 μg/mL	Antineoplastic activity against human SW620 colon tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human SW620 colon tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al

In Vitro

Rapamycin dialdehyde (48 h) exhibits antineoplastic activity against various solid tumor cell lines, including 3T3, 3T3/H2N, A431, SKBR3, MDA-435, and SW620, with IC₅₀ values ranging from 0.52 to 1.41 μg/mL^[1].
Rapamycin dialdehyde (168 h) promotes neurite outgrowth in SH-SY5Y cells, demonstrating neurotrophic activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 500733-49-3
Molecular Weight 946.17
Formula C₅₁H₇₉NO₁₅
SMILES

O=C([C@@]1(O[C@@H](CC[C@H]1C)C[C@H](OC)/C(C)=C/C=O)O)C(N2[C@@H](CCCC2)C(O[C@@H](CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C/C=O)=O)=O)[C@H](C)C[C@H]3C[C@H]([C@@H](CC3)O)OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhu T, et al. Rapamycin dialdehydes. WO2003018574A1. WIPO(PCT). 2003.

[2]. Inayat-Hussain, et al. Recent advances in the discovery and development of stilbenes and lactones in anticancer therapy. Expert Opinion on Therapeutic Patents, 14(6), 819-835.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Rapamycin dialdehyde