1. Apoptosis
  2. RIP kinase
  3. RIPK3-IN-2

RIPK3-IN-2 

Cat. No.: HY-148052
Handling Instructions

RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research.

For research use only. We do not sell to patients.

RIPK3-IN-2 Chemical Structure

RIPK3-IN-2 Chemical Structure

CAS No. : 2665669-32-7

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Description

RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research[1].

In Vitro

RIPK3-IN-2 (0.3-20 μM; 42 h) inhibits HT-29 cell growth[1].
RIPK3-IN-2 (0.3-20 μM; 14 h) inhibits MEF cell growth[1].
RIPK3-IN-2 (0.3-20 μM; 18 h) inhibits L929 cell growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HT-29 cells
Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM
Incubation Time: 42 hours
Result: Showed EC50 value of 0.085 μM.

Cell Viability Assay[1]

Cell Line: MEF cells
Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM
Incubation Time: 14 hours
Result: Showed EC50 value of 0.24 μM.

Cell Viability Assay[1]

Cell Line: L929 cells
Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM
Incubation Time: 18 hours
Result: Showed EC50 value of 0.21 μM.
Molecular Weight

441.95

Formula

C21H16ClN3O2S2

CAS No.
SMILES

O=S1(C=C(C2CC2)C3=C1C=C4C(NC5=CC6=C(SC=N6)C=C5)=CC=NC4=C3)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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RIPK3-IN-2
Cat. No.:
HY-148052
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