Rivanicline-d3
Rivanicline-d3 (RJR-2403-d3) is the deuterium labeled Rivanicline. Rivanicline (RJR-2403) is a neuronal nicotinic receptor agonist..
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- CAS. Nr.: 220088-40-4
- Formel: C10H11D3N2
- Molecular Weight:165.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Animal Model:Scopolamine (1.3 μmol/kg)-induced passive amnesia model established in male wistar rats (200-220 g)[2]
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Dosage:0.06, 0.6, 6 µmol/kg
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Administration:Subcutaneous Injections (s.c.), 30 min before testing
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Result:Reversed scopolamine-induced amnesia, increasing step-through latency at 0.6 µmol/kg.
No effect at 0.06 or 6 µmol/kg.
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Animal Model:Ibotenic acid lesion radial arm maze model established in male Sprague-Dawley rats (250–270 g) [2]
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Dosage:0, 0.3, 0.6, 0.9, 1.2 µmol/kg
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Administration:Subcutaneous Injections (s.c.), 20 min before testing
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Result:Improved working memory (place task) in lesioned rats.
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Animal Model:Physiological test battery model established in C57BL/6 mice[2]
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Dosage:75, 100 and 125 µmol/kg
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Administration:Subcutaneous Injections (s.c.), single dose
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Result:Was 15-50x less potent than nicotine in reducing body temperature, respiration, and locomotor activity.
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Animal Model:MK-801 (0.02 mg/kg)-induced impairment of eyeblink conditioning model established in C57Bl/6 mice (3-5 months)[4]
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Dosage:2 mg/kg
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Administration:Intraperitoneal injection (i.p.), single dose
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Result:Rescues learning by activating presynaptic nAChRs to enhance glutamate release.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 220088-40-4
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Unlabeled Cas 15585-43-0
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Molecular Weight 165.25
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Formel C10H11D3N2
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SMILES
[2H]C([2H])(NCC/C=C/C1=CC=CN=C1)[2H]
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Synonyms
RJR-2403-d3; (E)-Metanicotine-d3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21. [Content Brief]
[2]. Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9. [Content Brief]
[3]. Papke RL, et al The activation and inhibition of human nicotinic acetylcholine receptor by RJR-2403 indicate a selectivity for the alpha4beta2 receptor subtype. J Neurochem. 2000 Jul;75(1):204-16. [Content Brief]
[4]. Rodríguez-Moreno A, et al. The nicotinic agonist RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801. Neurosci Lett. 2006 Jul 10;402(1-2):102-7. [Content Brief]
[5]. Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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