Rolapitant-d4
Rolapitant-d4 (SCH619734-d4) is the deuterated-labeled Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.
For research use only. We do not sell to patients.
- Formula: C25H22D4F6N2O2
- Molecular Weight:504.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 552292-08-7
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Molecular Weight 504.50
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Formula C25H22D4F6N2O2
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SMILES
FC(F)(F)C1=CC(C(F)(F)F)=CC(C(C([2H])([2H])[2H])([2H])OC[C@]2(C3=CC=CC=C3)CC[C@]4(NC(CC4)=O)CN2)=C1
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Synonyms
SCH619734-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rolapitant-d4 Related Classifications
HY-14751S Related Classifications
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