2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. RORγt inverse agonist 30

RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders.

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RORγt inverse agonist 30 Chemical Structure

RORγt inverse agonist 30 Chemical Structure

CAS No. : 1445901-41-6

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RORγt inverse agonist 30 Related Antibodies

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Description

RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1].

IC50 & Target[1]

RORγt

46 nM (IC50)

In Vitro

RORγt inverse agonist 30 (compound 1) inhibits mouse Th17 cell differentiation with an IC50 of 0.67 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RORγt inverse agonist 30 Related Antibodies
In Vivo

RORγt inverse agonist 30 exhibits favorable pharmacokinetics profiles with T1/2 of 2.3 min, CLint of 612 μL/min/mg and CLint(liver) of 2423.5 mL/min/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

441.59

Formula

C24H31N3O3S
CAS No.
SMILES

CC(N1CCN(CC1)C2=CC=C(C=C2)CN(S(=O)(CC3=CC=CC=C3)=O)C4CCC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RORγt inverse agonist 30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RORγt inverse agonist 301445901-41-6RORγt inverse agonist30RORγt inverse agonist-30RORRAR-related orphan receptorRetinoic acid receptororphan receptorRORγtInverse agonistTh17 cellsMetabolic stabilityPsoriasisInhibitorinhibitorinhibit

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RORγt inverse agonist 30
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HY-147533
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