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Cat. No.: HY-153983

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RXRα‌ modulator-1

RXRα modulator-1 is an RXRα modulator that binds to the RXRα ligand-binding domain. RXRα modulator-1 can be used in tumor-related research.

For research use only. We do not sell to patients.

CAS No.: 1346513-28-7
Formula: C₂₀H₁₄F₄O₂
Molecular Weight:362.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

RXRα‌ modulator-1 Chemical Structure

CAS No.: 1346513-28-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

RXRα modulator-1 is an RXRα modulator that binds to the RXRα ligand-binding domain. RXRα modulator-1 can be used in tumor-related research^[1].

IC₅₀ & Target

RXR α

4.73 μM (IC₅₀)

All RAR/RXR Isoforms :

In Vitro

RXRα modulator-1 (Compound 4) binds to GST-tagged human RXRα-LBD in a ligand-binding competition assay with an IC₅₀ of 4.73 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1346513-28-7
Molecular Weight 362.32
Formula C₂₀H₁₄F₄O₂
SMILES

C(C(O)=O)C=1C=2C(/C(=C\C3=CC=C(C(F)(F)F)C=C3)/C1C)=CC=C(F)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang ZG, et al. Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation. European journal of medicinal chemistry. 2013 Apr;62:632-48.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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