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Cat. No.: HY-11053G

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S 24795 (GMP)

S 24795 (GMP) is GMP grade S 24795 (HY-11053). GMP grade small molecules can be used as adjuvants in cell therapy. S 24795 (GMP) is a partial agonist of α7 nAChR, which can improve memory function in aging mice and is used to study age-related memory disorders.

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CAS No.: 304679-75-2
Formule: C₁₄H₁₃BrINO
Masse moléculaire:418.07

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Please store the product under the recommended conditions in the Certificate of Analysis.

S 24795 (GMP) Chemical Structure

CAS No.: 304679-75-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 304679-75-2
Masse moléculaire 418.07
Formule C₁₄H₁₃BrINO
SMILES

O=C(CC1=[N+](C)C=CC=C1)C2=CC=C(C=C2)Br.[I-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Directly Induced Neuron Culture
Directly induced neuron culture converts somatic cells, most commonly fibroblasts, into induced neurons without passing through a pluripotent or neural progenitor stage; classic evidence shows that mouse fibroblasts can be converted by Ascl1, Brn2/Pou3f2, and Myt1l, human fibroblasts can be converted by defined neuronal transcription factors, and human fibroblasts can also be converted by miR-9/9-124 with neurogenic or subtype-specifying transcription factors. The readout is acquisition of neuronal identity and function, assessed by neuronal morphology, neuronal markers such as Tuj1/βIII-tubulin, MAP2, synapsin, and subtype markers when relevant, together with functional assays such as action-potential firing, synaptic activity, and electrophysiology.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lagostena L, et al. The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology. 2008 Mar;54(4):676-85. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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