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Cat. No.: HY-186166

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(S)-Embibatinib

Name: (S)-Embibatinib
Brand: MedChemExpress
SKU: HY-186166
Availability: PreOrder

(Synonyms: (S)-TERN-701)

(S)-Embibatinib ((S)-TERN-701), an isomer of TERN-701 (HY-182792), is a selective BCR-ABL allosteric inhibitor. (S)-Embibatinib can be usd for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2412969-12-9
Formula: C₂₃H₁₈ClF₄N₅O₃
Molecular Weight:523.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-Embibatinib Chemical Structure

CAS No.: 2412969-12-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

(S)-Embibatinib ((S)-TERN-701), an isomer of TERN-701 (HY-182792), is a selective BCR-ABL allosteric inhibitor. (S)-Embibatinib can be usd for the research of cancer^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

In Vitro

(S)-Embibatinib (Compound 231) shows CC₅₀ of 13.52 nM for Abl K562 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2412969-12-9
Molecular Weight 523.87
Formula C₂₃H₁₈ClF₄N₅O₃
SMILES

C[C@@H](CO)N1C(C(F)F)=NC2=C1C(C3=CN=CN=C3)=CC(C(NC4=CC=C(OC(Cl)(F)F)C=C4)=O)=C2
Synonyms

(S)-TERN-701
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. F. Anthony Romero, et al. Compounds for treating certain leukemias. WO2020061086A2. 2021-03-18

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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