2. GPCR/G Protein Immunology/Inflammation
  3. Leukotriene Receptor FLAP
  4. (S)-Veliflapon

(S)-Veliflapon  (Synonyms: (S)-BAY X 1005; (S)-DG-031)

Cat. No.: HY-14165A Purity: 99.44%
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(S)-Veliflapon ((S)-BAY X 1005) is an orally active inhibitor of leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP). (S)-Veliflapon inhibits the formation of leukotriene B4 (LTB4) in rat, mouse and human leukocytes with IC50 values of 0.026 µM, 0.039 µM and 0.22 µM respectively. (S)-Veliflapon showes enantioselectivity in human whole blood.

For research use only. We do not sell to patients.

(S)-Veliflapon Chemical Structure

(S)-Veliflapon Chemical Structure

CAS No. : 128253-32-7

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5 mg USD 250 In-stock
10 mg USD 400 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2050 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-Veliflapon:

(S)-Veliflapon Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

(S)-Veliflapon ((S)-BAY X 1005) is an orally active inhibitor of leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP). (S)-Veliflapon inhibits the formation of leukotriene B4 (LTB4) in rat, mouse and human leukocytes with IC50 values of 0.026 µM, 0.039 µM and 0.22 µM respectively. (S)-Veliflapon showes enantioselectivity in human whole blood[1][2][3].

In Vitro

(S)-Viliflapon decreases leukotriene B4 (LTB4) synthesis in human whole blood with dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Veliflapon Related Antibodies
Molecular Weight

361.43

Formula

C23H23NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](C1CCCC1)C(C=C2)=CC=C2OCC3=NC4=CC=CC=C4C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (276.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7668 mL 13.8339 mL 27.6679 mL
5 mM 0.5534 mL 2.7668 mL 5.5336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7668 mL 13.8339 mL 27.6679 mL 69.1697 mL
5 mM 0.5534 mL 2.7668 mL 5.5336 mL 13.8339 mL
10 mM 0.2767 mL 1.3834 mL 2.7668 mL 6.9170 mL
15 mM 0.1845 mL 0.9223 mL 1.8445 mL 4.6113 mL
20 mM 0.1383 mL 0.6917 mL 1.3834 mL 3.4585 mL
25 mM 0.1107 mL 0.5534 mL 1.1067 mL 2.7668 mL
30 mM 0.0922 mL 0.4611 mL 0.9223 mL 2.3057 mL
40 mM 0.0692 mL 0.3458 mL 0.6917 mL 1.7292 mL
50 mM 0.0553 mL 0.2767 mL 0.5534 mL 1.3834 mL
60 mM 0.0461 mL 0.2306 mL 0.4611 mL 1.1528 mL
80 mM 0.0346 mL 0.1729 mL 0.3458 mL 0.8646 mL
100 mM 0.0277 mL 0.1383 mL 0.2767 mL 0.6917 mL
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(S)-Veliflapon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Veliflapon128253-32-7(S)-BAY X 1005 (S)-DG-031Leukotriene ReceptorFLAP5-lipoxygenase-activating protein5-LO activating proteinLTB4VolunteersInhibitorinhibitorinhibit

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