S0456
Based on 1 Customer Validation
S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 1252007-83-2
- Formula: C38H44ClN2Na3O12S4
- Molecular Weight:953.44
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
In the design of OTL38 (HY-139579), S0456 is linked to the modified folic acid. S0456 not only serves as part of the ligand that binds to the folate receptor but also increases the delocalized electron system of the near-infrared dye to enhance fluorescence. The introduction of a phenoxy group via a vinyl ether bridge to S0456 can further enhance the fluorescence intensity and cause a blue shift in the spectrum. Ultimately, this imparts OTL38 (HY-139579) with good optical properties and targeting specificity for tumor tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1252007-83-2
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Appearance Solid
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Molecular Weight 953.44
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Formula C38H44ClN2Na3O12S4
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Color Green to dark green
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SMILES
O=[S](CCCCN(/C1=C/C=C(CCC2)/C(Cl)=C2/C=C/C(C(C)(C3=C4)C)=[N+](C3=CC=C4[S](=O)([O-])=O)CCCC[S](=O)(O[Na])=O)C(C(C1(C)C)=C5)=CC=C5[S](=O)(O[Na])=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 33.33 mg/mL (34.96 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0488 mL | 5.2442 mL | 10.4883 mL | 26.2208 mL |
| 5 mM | 0.2098 mL | 1.0488 mL | 2.0977 mL | 5.2442 mL | |
| 10 mM | 0.1049 mL | 0.5244 mL | 1.0488 mL | 2.6221 mL | |
| 15 mM | 0.0699 mL | 0.3496 mL | 0.6992 mL | 1.7481 mL | |
| 20 mM | 0.0524 mL | 0.2622 mL | 0.5244 mL | 1.3110 mL | |
| 25 mM | 0.0420 mL | 0.2098 mL | 0.4195 mL | 1.0488 mL | |
| 30 mM | 0.0350 mL | 0.1748 mL | 0.3496 mL | 0.8740 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
S0456 Related Classifications
HY-D1716 Related Classifications
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