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Cat. No.: HY-12965A

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S49076 hydrochloride

Name: S49076 hydrochloride
Brand: MedChemExpress
SKU: HY-12965A
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

S49076 hydrochloride is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC₅₀ values below 20 nM.

For research use only. We do not sell to patients.

CAS No.: 1265966-31-1
Formula: C₂₂H₂₃ClN₄O₄S
Molecular Weight:474.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

S49076 hydrochloride Chemical Structure

CAS No.: 1265966-31-1

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Use of MCE Products

Fluorescent Dye

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Biological Activity

Description

S49076 hydrochloride is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC₅₀ values below 20 nM.

Chemical Information

CAS No. 1265966-31-1
Molecular Weight 474.96
Formula C₂₂H₂₃ClN₄O₄S
SMILES

O=C(N1CC2=CC3=C(NC(/C3=C\C4=CC(CN5CCOCC5)=CN4)=O)C=C2)SCC1=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Nat Commun

AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy. [Abstract]

2019 Apr 18;10(1):1812. PMID: 31000705

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL (65.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1054 mL

10.5272 mL

21.0544 mL

5 mM

0.4211 mL

2.1054 mL

4.2109 mL

10 mM

0.2105 mL

1.0527 mL

2.1054 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Burbridge MF, et al. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol Cancer Ther. 2013 Sep;12(9):1749-62. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1054 mL	10.5272 mL	21.0544 mL	52.6360 mL
	5 mM	0.4211 mL	2.1054 mL	4.2109 mL	10.5272 mL
	10 mM	0.2105 mL	1.0527 mL	2.1054 mL	5.2636 mL
	15 mM	0.1404 mL	0.7018 mL	1.4036 mL	3.5091 mL
	20 mM	0.1053 mL	0.5264 mL	1.0527 mL	2.6318 mL
	25 mM	0.0842 mL	0.4211 mL	0.8422 mL	2.1054 mL
	30 mM	0.0702 mL	0.3509 mL	0.7018 mL	1.7545 mL
	40 mM	0.0526 mL	0.2632 mL	0.5264 mL	1.3159 mL
	50 mM	0.0421 mL	0.2105 mL	0.4211 mL	1.0527 mL
	60 mM	0.0351 mL	0.1755 mL	0.3509 mL	0.8773 mL

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S49076 hydrochloride

1 Cited Publications

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S49076 hydrochloride

Publications Citing Use of MedChemExpress (MCE) S49076 hydrochloride