TRA2B - transformer 2 beta homolog Gene

Also Known as SFRS10; SRFS10; TRAN2B; PPP1R156; TRA2-BETA; Htra2-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6434

About TRA2B

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,914,558-185,938,014 (from NCBI)

This gene has 15 transcripts (splice variants), 542 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 41.9), lymph node (RPKM 15.3) and 25 other tissues.

Summary

This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

TRA2B Products (2)

mRNA Protein Name
NM_001243879.2 NP_001230808.1 transformer-2 protein homolog beta isoform 2
NM_004593.3 NP_004584.1 transformer-2 protein homolog beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IMP
IMP: Inferred from mutant phenotype
10749975 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
10749975 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
12165565 GOA
enables pre-mRNA binding IDA
IDA: Inferred from direct assay
25689357 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10749975 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10749975 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
25689357 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
9546399 GOA
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
10749975 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
12165565 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
25689357 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9546399 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
10749975 GOA
part of spliceosomal complex IMP
IMP: Inferred from mutant phenotype
25689357 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRA2B Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (122 - 190)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

transformer-2 protein homolog beta

  • TRA-2 beta

TRA2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRA2B P62995 PCDHB14 Homo sapiens Q9Y5E9
Validated Y2H
32296183
Intra
TRA2B P62995 SRSF8 Homo sapiens Q9BRL6-2
Validated Y2H
32296183
Intra
TRA2B P62995 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra
TRA2B P62995 YTHDC1 Homo sapiens Q96MU7
Y2H
21988832
Intra
TRA2B P62995 YTHDC1 Homo sapiens Q96MU7
Validated Y2H
32296183
Intra
TRA2B P62995 MYPOP Homo sapiens Q86VE0
Validated Y2H
32296183
Intra
TRA2B P62995 SRSF9 Homo sapiens Q13242
Validated Y2H
32296183
Intra
TRA2B P62995 SRSF9 Homo sapiens Q13242
Y2H Prey Pooling
32296183
Intra
TRA2B P62995 SRSF9 Homo sapiens Q13242
Y2H Array
32296183
Intra
TRA2B P62995 SRSF1 Homo sapiens Q07955
Validated Y2H
32296183
Intra
TRA2B P62995 SRPK2 Homo sapiens P78362
Validated Y2H
32296183
Intra
TRA2B P62995 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra
TRA2B P62995 SRSF4 Homo sapiens Q08170
Y2H
22365833
Intra
TRA2B P62995 SRSF4 Homo sapiens Q08170
Validated Y2H
32296183
Intra
TRA2B P62995 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra
TRA2B P62995 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra
TRA2B P62995 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra
TRA2B P62995 MAGOHB Homo sapiens Q96A72
Validated Y2H
32296183
Intra
TRA2B P62995 RBMY1F Homo sapiens Q15415
Validated Y2H
32296183
Intra
TRA2B P62995 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra
TRA2B P62995 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRA2B Proteins

Cat. No. Product Name Accession Purity
HY-P72056 TRA2B Protein, Human (sf9, His-Myc) P62995 (S2-Y288) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spinal Muscular Atrophy

  • Sma

  • 5q Sma

  • Proximal Sma

  • Sma-Associated Sma

  • Spinal Amyotrophies

  • Spinal Amyotrophy

  • Spinal Muscle Degeneration

  • Spinal Muscle Wasting

  • Muscular Atrophy Spinal

  • Atrophy, Muscular, Spinal

  • Hereditary Motor Neuronopathy

  • Progressive Muscular Atrophy

  • Sma - [Spinal Muscular Atrophy]
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14962 TRA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19488 Tra2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25982 Tra2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TRA2B VGNC VGNC:47759
Felis catus TRA2B VGNC VGNC:66491
Bos taurus TRA2B VGNC VGNC:36268
Macaca mulatta TRA2B VGNC VGNC:78554
Rattus norvegicus TRA2B RGD RGD:619886
Mus musculus TRA2B MGD MGI:106016
Others TRA2B NCBI