YW2036
Based on 1 Customer Validation
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. YW2036 can be used in research of colorectal cancer (CRC).
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 2131223-92-0
- Formula: C20H16N4O
- Molecular Weight:328.37
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| SW480 | GI50 |
23.9 μM
Compound: 1a
|
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
|
[PMID: 31769984] |
Chemical Information
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CAS No. 2131223-92-0
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Appearance Solid
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Molecular Weight 328.37
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Formula C20H16N4O
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Color White to off-white
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SMILES
O=C(C1=C(C)N(C2=CC=CC=C2)N=C1)NC3=CC=C4C=CC=CC4=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (380.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0453 mL | 15.2267 mL | 30.4535 mL | 76.1336 mL |
| 5 mM | 0.6091 mL | 3.0453 mL | 6.0907 mL | 15.2267 mL | |
| 10 mM | 0.3045 mL | 1.5227 mL | 3.0453 mL | 7.6134 mL | |
| 15 mM | 0.2030 mL | 1.0151 mL | 2.0302 mL | 5.0756 mL | |
| 20 mM | 0.1523 mL | 0.7613 mL | 1.5227 mL | 3.8067 mL | |
| 25 mM | 0.1218 mL | 0.6091 mL | 1.2181 mL | 3.0453 mL | |
| 30 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5378 mL | |
| 40 mM | 0.0761 mL | 0.3807 mL | 0.7613 mL | 1.9033 mL | |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL | |
| 60 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 80 mM | 0.0381 mL | 0.1903 mL | 0.3807 mL | 0.9517 mL | |
| 100 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.7613 mL |