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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
98 Results for "
Cardiotoxicity
" in MedChemExpress (MCE) Product Catalog:
Products (98)
98 Results for "Cardiotoxicity" in MCE Product Catalog:
711
711 Publications Verification
Synonyms: Hydroxydaunorubicin hydrochloride; ADR
131
131 Cited Publications
Synonyms: tert-Butylhydroquinone
Áreas de investigación:
TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2 . TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma .
13
13 Cited Publications
Referencia número: HY-N0390S1
No. CAS: 184161-19-1
Synonyms: L-Glutamic acid 5-amide-13C5
12
12 Cited Publications
Synonyms: GSK-AHAB; GW856553X; SB856553
Target:
Áreas de investigación:
Cardiovascular Disease Infection Neurological Disease Cancer
Losmapimod (GSK-AHAB; GW856553X) is an orally active p38α/β MAPK inhibitor, with pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Losmapimod reduces DUX4 expression, thus exerting efficacy in facioscapulohumeral muscular dystrophy. By inhibiting MAPK/NF-κB, Losmapimod reduces apoptosis of epileptiform hippocampal neurons, and exhibits anti-allodynia and anti-hyperalgesic activities. Losmapimod blocks the entry and fusion of Lassa fever virus (LASV). Losmapimod overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Losmapimod inhibits myocardial senescence and inflammation, and possesses cardioprotective activity against cardiotoxicity .
9
Target:
Serotonin Transporter 5-HT Receptor mAChR Histamine Receptor Adrenergic Receptor Trk Receptor Sodium Channel Potassium Channel Dopamine Transporter Apoptosis
Áreas de investigación:
Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with Ki = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity .
9
Target:
Serotonin Transporter Trk Receptor Sodium Channel 5-HT Receptor Histamine Receptor Adrenergic Receptor mAChR Potassium Channel Dopamine Transporter Apoptosis
Áreas de investigación:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Amitriptyline is an orally active tricyclic antidepressant (TCA). Amitriptyline mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline can reduce inflammation, angiogenesis and fibrosis. Amitriptyline binds to DAT (with Ki = 2.58 μM). Amitriptyline has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity .
8
8 Cited Publications
Synonyms: Kaempferol-3-O-rhamnoside
5
5 Cited Publications
Referencia número: HY-15142R
No. CAS: 25316-40-9
Synonyms: Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)
Category:
5
4
4 Cited Publications
Referencia número: HY-N0390S
No. CAS: 80143-57-3
Synonyms: L-Glutamic acid 5-amide-15N
4
4 Cited Publications
Referencia número: HY-N0390S9
No. CAS: 59681-32-2
Synonyms: L-Glutamic acid 5-amide-15N-1
4
3
3 Cited Publications
Synonyms: Creatine phosphate; Creatinephosphoric acid
3
3 Cited Publications
Synonyms: Disodium creatine phosphate
3
3 Cited Publications
Referencia número: HY-D0885D
No. CAS: 19333-65-4
2
2
Category:
Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Inflammation/Immunology
Target:
2
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-N0390S8
No. CAS: 204451-48-9
Synonyms: L-Glutamic acid 5-amide-15N2
1
1 Cited Publications
Referencia número: HY-N0390S2
No. CAS: 14341-78-7
Synonyms: L-Glutamic acid 5-amide-d5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
