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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
316 Results for "
PR
" in MedChemExpress (MCE) Product Catalog:
Products (316)
316 Results for "PR" in MCE Product Catalog:
80
80 Publications Verification
Synonyms: DMXAA; ASA-404
Target:
Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.
80
80 Publications Verification
Synonyms: RU486; RU 38486
Forschungsgebiete:
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay .
77
Target:
Forschungsgebiete:
Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.
40
Target:
Forschungsgebiete:
PR-619 is a broad-range and reversible DUB inhibitor with EC50s of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis .
26
Target:
Forschungsgebiete:
ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .
26
Target:
Forschungsgebiete:
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .
8
8 Cited Publications
Target:
Forschungsgebiete:
W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
8
8 Cited Publications
Target:
Forschungsgebiete:
W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
8
8 Cited Publications
Art. -Nr.: HY-B0689
CAS. Nr.: 150378-17-9
Synonyms: MK-639 free base; L-735524 free base
Target:
Forschungsgebiete:
Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL pro inhibitor .
8
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CL pro inhibitor .
4
4 Cited Publications
Synonyms: ONX 0912; PR-047
Target:
Forschungsgebiete:
Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells .
4
4 Cited Publications
Art. -Nr.: HY-B1899A
CAS. Nr.: 110026-03-4
Synonyms: Taurodeoxycholate sodium hydrate
4
4
Category:
4
4 Cited Publications
Art. -Nr.: HY-N1423B
CAS. Nr.: 1192657-83-2
3
3 Cited Publications
Target:
Forschungsgebiete:
CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection .
3
3 Cited Publications
Synonyms: (S)-FTY720P; (S)-FTY720 phosphate
Target:
Forschungsgebiete:
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
3
3 Cited Publications
Synonyms: CC-94676
Target:
Forschungsgebiete:
BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader (DC50 of 10-40 nM). BMS-986365 is capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows no degradation of the close AR family members estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. BMS-986365 can be used for the study of metastatic castration-resistant prostate cancer (mCRPC) .
3
3 Cited Publications
Art. -Nr.: HY-P7515
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ANXA2; Annexin-2; PRev. ANX2L4; PAP-IV; PRev. CAL1H; P36; PRev. LPC2D; Epididymis Secretory Sperm Binding PRotein; PRev. ANX2; Epididymis Secretory PRotein Li 270; Annexin II; Calpactin I Heavy Polypeptide; LIP2; Chromobindin 8; Placental Anticoagulant PR
Species:
Human
Source:
E. coli
2
2 Cited Publications
Synonyms: R-5020; Surgestone
Target:
Forschungsgebiete:
Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
