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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
355 Results for "
Domain B
" in MedChemExpress (MCE) Product Catalog:
Products (355)
355 Results for "Domain B" in MCE Product Catalog:
Cat. No.: HY-P76924A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCRL2; SH2 Domain Containing Phosphatase Anchor Protein 1; Prev. SPAP1; Immunoglobulin Superfamily Fc Receptor, Gp42; FCRH2; Fc Receptor-Like 2; IRTA4; FcR-Like Protein 2; CD307b; CD307b Antigen; Immunoglobulin Receptor Translocation-Associated Protein 4
Species:
Human
Source:
HEK293
Cat. No.: HY-P703955
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: FCRL2; SH2 Domain Containing Phosphatase Anchor Protein 1; Prev. SPAP1; Immunoglobulin Superfamily Fc Receptor, Gp42; FCRH2; Fc Receptor-Like 2; IRTA4; FcR-Like Protein 2; CD307b; CD307b Antigen; Immunoglobulin Receptor Translocation-Associated Protein 4
Species:
Human
Source:
HEK293
Cat. No.: HY-P87433A
Synonyms: CD307b, FCRH2, IFGP4, IRTA4, SPAP1, UNQ9236/PRO31998, FCRL2, Fc receptor-like protein 2, FcR-like protein 2, FcRL2, Fc receptor homolog 2, IFGP family protein 4, Immunoglobulin receptor translocation-associated protein 4, SH2 Domain-containing phosphatase anchor protein 1, FcRH2
Cat. No.: HY-162775
CAS No.: 50566-97-7
Target:
Research Areas:
TST1N-224 is a potent response regulator VraRC inhibitor. TST1N-224 can disrupt VraRC-DNA complex formation (IC50=60.2 μM). TST1N-224 exhibits interference with VraRC binding to its cognate DNA through a fast-on-fast-off binding mechanism (KD=23.4 μM). TST1N-224 predominantly interacts with the α9- and α10-helixes of the DNA-binding domain of VraR. TST1N-224 inhibits the growths of S. aureus (SA; MIC>126 μM), Methicillin-resistant S. aureus (MRSA; MIC>126 μM), and Vancomycin-intermediate S. aureus (VISA; MIC=63 μM). TST1N-224, an antimicrobial agent, evidently enhances the susceptibility of VISA to both Vancomycin (HY-B0671) and Methicillin (HY-B0974) .
Cat. No.: HY-P72779
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript Variant 1, MRNA; TRAIL-R2; P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer); TRAILR2; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9; KILLER; Death Domain Containing Receptor For TRAIL/Apo-2L; DR5; Apoptosis Inducing Protein TRICK2A/2B; Tumor Necrosis Factor Receptor Superfamily, Member 10b; Apoptosis Inducing Receptor TRAIL-R2; Tumor Necrosis Factor Receptor Superfamily Member 10B; Cytotoxic TRAIL Receptor-2; TRICK2A; TNFRSF10B Protein; TRICKB; Fas-Like Protein; CD262; TRAIL Receptor 2; TNF-Related Apoptosis-Inducing Ligand Receptor 2; CD262 Antigen; Death Receptor 5; KILLER/DR5; TRICK2; TRICK2B
Species:
Human
Source:
E. coli
Cat. No.: HY-172085
CAS No.: 3099543-90-2
Target:
Research Areas:
SH514 is an orally active IRF4 inhibitor (IC50 = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors .
Cat. No.: HY-P701064
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB4; CD85 Antigen-Like Family Member K; Leukocyte Immunoglobulin Like Receptor B4; Monocyte Inhibitory Receptor HM18; LIR-5; Immunoglobulin-Like Transcript 3; ILT3; Leucocyte Ig-Like Receptor B4; LIR5; ILT-3; CD85k; HM18; Leukocyte Immunoglobulin-Like
Species:
Human
Source:
HEK293
Cat. No.: HY-P701065
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB4; CD85 Antigen-Like Family Member K; Leukocyte Immunoglobulin Like Receptor B4; Monocyte Inhibitory Receptor HM18; LIR-5; Immunoglobulin-Like Transcript 3; ILT3; Leucocyte Ig-Like Receptor B4; LIR5; ILT-3; CD85k; HM18; Leukocyte Immunoglobulin-Like
Species:
Human
Source:
HEK293
Cat. No.: HY-D3103
CAS No.: 1027058-07-6
Target:
Research Areas:
CMTDP is a Fluorescent probe for detecting local polarity changes around the Cys34 domain of bovine serum albumin during pH-induced N→B conformational transition. It is a thiol-specific and polarity-sensitive probe; it covalently labels the free cysteine residue at position 34 (Cys34) of bovine serum albumin, and its fluorescence maximum emission wavelength shifts in response to solvent polarity, but not to pH and temperature. When labeled to BSA, as the local polarity around the Cys34 domain increases with rising pH, the probe shows a bathchromic shift in fluorescence emission wavelength and a decrease in fluorescence intensity, which allows quantification of the local polarity change via the relationship between emission wavelength shift and dielectric constant. CMTDP itself has absorption peaks at ~392 and 508 nm, and CMTDP-labeled BSA has excitation maxima at 376 and 470 nm at pH 6.0, with the shorter-wavelength excitation peak red-shifting as pH increases while the longer one remains stable; when excited at 470 nm, the fluorescence emission maximum shifts from 570 nm at pH 6.0 to 577 nm at pH 9.1, while free CMTDP at pH 7.4 has an emission maximum at 621 nm. The excitation/emission wavelengths for CMTDP-labeled BSA are Ex/Em = 376/570 nm at pH 6.0, Ex/Em = ~376+/573 nm at pH 7.4, Ex/Em = ~376+/575 nm at pH 8.0, Ex/Em = ~376+/577 nm at pH 9.1, and for free CMTDP at pH 7.4, Ex/Em (when excited at 470 nm) = 470/621 nm[1].
Cat. No.: HY-183583
CAS No.: 2709068-47-1
Target:
Research Areas:
HIF-2α-IN-18 is a selective HIF-2α inhibitor with a human IC50 of 8.1 nM. HIF-2α-IN-18 binds to the HIF-2α PAS-B domain, induces conformational perturbations at the HIF-2α/ARNT dimerization interface, destabilizes the HIF-2α/ARNT heterodimer, and blocks HIF-2α-mediated transcriptional activity. HIF-2α-IN-18 inhibits hypoxia-induced expression of HIF-2α target genes EPO and SERPINE1, without inhibiting HIF-1α target genes PGK1 and PDK1. HIF-2α-IN-18 can be used for the research of clear cell renal cell carcinoma, hepatocellular carcinoma[1].
Cat. No.: HY-138830B
CAS No.: 1818252-52-6
Target:
Research Areas:
TAK-418 free base is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 free base irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 free base restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 free base rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 free base can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .
Cat. No.: HY-P73609
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HAVCR1; T-Cell Membrane Protein 1; Hepatitis A Virus Cellular Receptor 1; TIMD-1; TIM-1; KIM-1; TIMD1; TIM; TIM1; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1; KIM1; T Cell Immunoglobin Domain And Mucin Domain Protein 1; Kidney Injury Molecule 1; Hepatitis A Virus Cellular Receptor 1a; HAVCR-1; Hepatitis A Virus Cellular Receptor 1b; HAVCR; Hepatitis A Virus Cellular Receptor 1c; CD365; CD365 Antigen; T-Cell Immunoglobulin Mucin Family Member 1; HAVcr-1; T-Cell Immunoglobulin Mucin Receptor 1
Species:
Canine
Source:
HEK293
Cat. No.: HY-P85577
Synonyms: Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death Domain containing receptor for TRAIL/Apo 2L; Death Domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; OTTHUMP00000123492; OTTHUMP00000123493; p53 regulated DNA damage inducible cell death receptor; killer; p53 regulated DNA damage inducible cell death receptor; killer; TNF related apoptosis inducing ligand receptor 2; TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TR10B_HUMAN; TRAIL R2; TRAIL receptor 2; TRAIL-R2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; Tumor necrosis factor receptor superfamily, member 10b; ZTNFR9.
Cat. No.: HY-P811950
Synonyms: TRIAD3, UBCE7IP1, ZIN, RNF216, E3 ubiquitin-protein ligase RNF216, RING finger protein 216, RING-type E3 ubiquitin transferase RNF216, Triad Domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B
Cat. No.: HY-P78595
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:
Cynomolgus
Source:
E. coli
Cat. No.: HY-P705693
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CASP10; Caspase 10 Apoptosis-Related Cysteine Peptidase Isoform 3; Caspase 10; Caspase 10, Apoptosis-Related Cysteine Peptidase; MCH4; Caspase 10 Apoptosis-Related Cysteine Peptidase; FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2
Species:
Human
Source:
E. coli
Cat. No.: HY-P811950A
Synonyms: TRIAD3, UBCE7IP1, ZIN, RNF216, E3 ubiquitin-protein ligase RNF216, RING finger protein 216, RING-type E3 ubiquitin transferase RNF216, Triad Domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B
Cat. No.: HY-P4776
CAS No.: 202463-00-1
Target:
Research Areas:
Cat. No.: HY-P71719
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:
Pig
Source:
P. pastoris
Cat. No.: HY-P74590
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: RYBP; RING1 And YY1-Binding Protein; RING1 And YY1 Binding Protein; Ring1 Interactor RYBP; YEAF1; DED-Associated Factor; DEDAF; APAP-1; Death Effector Domain-Associated Factor; RING1 And YY1 Binding Protein, Isoform CRA_b; Apoptin-Associating Protein 1; Y
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
