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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
349 Results for "
cap
" in MedChemExpress (MCE) Product Catalog:
Products (349)
349 Results for "cap" in MCE Product Catalog:
Synonyms: RXP-470
Target:
Research Areas:
RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification .
Synonyms: AT-752 free base
Research Areas:
Arbemnifosbuvir (AT-752 free base) is an orally active inhibitor of DENV NS5 RdRp and MTase, and is also a guanosine nucleotide analog prodrug. Arbemnifosbuvir forms the active triphosphate metabolite AT‑9010 (HY-139165) in peripheral blood mononuclear cells, which competes with GTP to terminate RNA synthesis and binds to the GTP/RNA-cap site to inhibit 2'-O-methylation. Arbemnifosbuvir reduces viremia, improves survival, prevents weight loss, and decreases viral load in a mouse model of dengue virus. Arbemnifosbuvir can be used for research related to viral infections .
Cat. No.: HY-N2362S
CAS No.: 102029-81-2
Synonyms: DL-2-Aminopropionic acid-13C-1
Cat. No.: HY-N2362S1
CAS No.: 131157-42-1
Synonyms: DL-2-Aminopropionic acid-13C-3
Cat. No.: HY-145538
CAS No.: 146877-98-7
Synonyms: 5'-Deoxyguanylic acid disodium hydrate
Target:
Research Areas:
2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) .
Cat. No.: HY-164984A
Target:
Research Areas:
m3227G(5)ppp(5')A triammonium is the triammonium salt form of m3227G(5)ppp(5')A (HY-164984). m3227G(5)ppp(5')A triammonium is a specific mRNA molecule structure, which is composed of a 3227-methylguanine (m3227G) cap, a triphosphate group and an adenosine. m3227G(5)ppp(5')A triammonium affects the stability and translation efficiency of mRNA .
Cat. No.: HY-N2362S8
Synonyms: DL-2-Aminopropionic acid-d7
Cat. No.: HY-W975617
CAS No.: 479-54-9
Synonyms: Carthamidin
Target:
Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism Lactate Dehydrogenase Biochemical Assay Reagents
Research Areas:
4',5,7,8-Tetrahydroxyflavanone (Carthamidin) is a flavanone pigment. 4',5,7,8-Tetrahydroxyflavanone can be found in Carthamus tinctorius. 4',5,7,8-Tetrahydroxyflavanone induces ROS generation, oxidative stress, Apoptosis-mediated cell death, cell cycle arrest at G0/G1 phase, mitochondrial membrane potential collapse, and LDH leakage. 4',5,7,8-Tetrahydroxyflavanone exhibits anti-inflammatory, antioxidant, and neuroprotective effects, and acts as a reducing and capping agent for gold nanoparticles. 4',5,7,8-Tetrahydroxyflavanone can be used in breast cancer research .
Cat. No.: HY-N2362S9
CAS No.: 221080-39-3
Synonyms: DL-2-Aminopropionic acid-13C2,15N2
Cat. No.: HY-151829
CAS No.: 2616562-74-2
Target:
Research Areas:
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Cat. No.: HY-173172
CAS No.: 3076503-34-6
Research Areas:
MG-002 is an orally active eIF4A1 and eIF4A2 inhibitor with a human eIF4A1 IC50 of 43 nM. MG-002 prevents competent ribosome recruitment to mRNA, inhibits cap-dependent mRNA translation, and engages eIF4A2 via the same RNA clamping mechanism to inhibit mRNA translation. MG-002 induces G2/M cell cycle delay, induces apoptosis, suppresses synthesis of c-MYC and cyclin D1, and shows minimal overt toxicity in mice. MG-002 inhibits primary triple-negative breast cancer tumor growth, attenuates metastatic spread, and enhances anti-neoplastic activity of Doxorubicin (HY-15142A) in pre-clinical models .
Cat. No.: HY-N2362S7
CAS No.: 144476-54-0
Synonyms: DL-2-Aminopropionic acid-13C3-4
Cat. No.: HY-P80049
Synonyms: MCH5, CASP8, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, cap4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, FLICE, MACH
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
