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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10026 Results for "
ASO/siRNA lipidation
" in MedChemExpress (MCE) Product Catalog:
Products (10026)
10026 Results for "ASO/siRNA lipidation" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-W590532
CAS No.: 2566523-06-4
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
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Ulefnersen (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen can be used in the research of Amyotrophic Lateral Sclerosis (ALS) .
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Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
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1 Cited Publications
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .
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1 Cited Publications
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
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1 Cited Publications
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98N12-5 is a lipid delivery material that assembles to form lipid nanoparticles and mediates the intracellular delivery of siRNA to hepatocytes . 98N12-5 is used in RNA interference-related research .
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1 Cited Publications
Synonyms: ION-363 sodium
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Ulefnersen sodium (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen sodium can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen sodium can be used in the research of Amyotrophic Lateral Sclerosis (ALS) .
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1 Cited Publications
Cat. No.: HY-132581A
Purity: 90.06%
Synonyms: BIIB078 sodium; IONIS-C9Rx sodium
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Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
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1 Cited Publications
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
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1 Cited Publications
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
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1 Cited Publications
Cat. No.: HY-145799A
Purity: 98.03%
5A2-SC8 TFA is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 TFA LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
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1 Cited Publications
Cat. No.: HY-D1378
CAS No.: 959839-06-6
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C-Laurdan is a modified Laurdan (HY-D0080) probe that imaging lipid rafts with environmentally sensitive fluorescence. C-Laurdan can be used in research of lipid arrangement and fluidity in biological membranes or artificial lipid membranes .
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1 Cited Publications
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
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1 Cited Publications
Cat. No.: HY-156822
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FAM-labeled siRNA Negative Control is a fluorescently labeled negative control in the siRNA set.
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1 Cited Publications
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Dlin-MeOH is an intermediate in the synthesis of DLin-MC3-DMA (HY-112251), which serves as an ionizable lipid component of lipid nanoparticles for mRNA delivery .
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1 Cited Publications
Cat. No.: HY-N15956
CAS No.: 3056014-11-7
DMG-PEG(2k)-DBCO is a Clickable PEG lipid containing a DBCO group. DSPE-PEG8-DBCO can be used to prepare lipid nanoparticles for drug delivery.
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1 Cited Publications
Cat. No.: HY-168374
CAS No.: 1829524-73-3
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DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume .
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1 Cited Publications
Cat. No.: HY-N3220
CAS No.: 15648-86-9
Category:
Flavonols Flavonoids Rhododendron dauricum Linn. Metabolic Disease Phenols Polyphenols Ericaceae Extract Plants Disease Research Fields
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
