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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
FtsZ
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "FtsZ" in MCE Product Catalog:
Cat. No.: HY-168630
CAS No.: 3042897-74-2
FtsZ-IN-11 (compound B6) is a FtsZ inhibitor with the IC50 of 235 μM against XooFtsZ. FtsZ-IN-11 can interact with XooFtsZ and inhibit its GTPase activity, leading to bacterial cell elongation and even death .
Cat. No.: HY-173277
CAS No.: 914357-88-3
FtsZ-IN-13 (Compound C11) is an inhibitor of temperature-sensitive mutant Z (FtsZ), with IC50 values of 47.97, 34 μM against FtsZSa and FtsZPa, respectively. FtsZ-IN-13 has a notable antimicrobial activity against S. aureus (minimum inhibitory concentration value of 2 μg/mL), cystic fibrosis S. aureus clinical isolates, and methicillin-resistant S. aureus (MRSA) strains. FtsZ-IN-13 can be used for antimicrobial resistance study .
Target:
Cat. No.: HY-119648
CAS No.: 1287652-03-2
CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC50 value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC50 value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents .
Cat. No.: HY-110354R
CAS No.: 1094451-90-7
Synonyms: G28UCM (Standard)
Research Areas:
UCM05 (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections [1][2][3].
Cat. No.: HY-111396
CAS No.: 434910-94-8
PC58538 is a cell division inhibitor, targeting to FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis. PC58538 is also known to modulate the rate of GTP hydrolysis .
Cat. No.: HY-157808
Antibacterial agent 185 (compound IP-01) is a potent antibacterial agent. Antibacterial agent 185 inhibits filamentous temperature-sensitive mutant Z (FtsZ) polymerization and bundling by increasing GTP hydrolysis. Antibacterial agent 185 inhibits Streptococcus pneumoniae and shows narrow-spectrum activity .
Cat. No.: HY-187991
FtsZ-IN-16 is a curcumin derivative and also an inhibitor of XooFtsZ, with an EC50 of 3.74 μg/mL against Xoo. FtsZ-IN-16 targets the FtsZ residues LEU71, GLY74, GLY110 and THR111 of Xanthomonas oryzae pv. oryzae, thereby blocking GTPase (GTPase) activity and polymerization. FtsZ-IN-16 can be used in studies related to rice bacterial blight .
Cat. No.: HY-184334
FtsZ-IN-15 is an inhibitor targeting the FtsZ protein of Xanthomonas oryzae pv. oryzae (Xoo) and a cell division inhibitor. FtsZ-IN-15 specifically binds to key residues of XooFtsZ, inhibits its GTPase activity and disrupts its polymerization. FtsZ-IN-15 induces cell elongation of Xanthomonas oryzae pv. oryzae and exhibits significant antibacterial activity against this strain. FtsZ-IN-15 shows good control efficacy against rice bacterial blight and can be used in relevant research on rice bacterial blight .
Cat. No.: HY-125533
CAS No.: 1404289-52-6
TXA497 is a potent local topical bactericide. TXA497 exerts its bactericidal effect by interfering with the polymerization kinetics of the bacterial cell division protein FtsZ, rather than inhibiting it. TXA497 shows strong activity against various Staphylococcus aureus strains, including MRSA and MSSA, with an MIC value ranging from 1.0 to 2.0 μg/mL. TXA497 skin deposition is concentration-dependent in its formulation, consistent with Fick's first law. TXA497 has limited systemic permeability through the lipid pathway of the stratum corneum and is easily absorbed through this route. TXA497 can be used for research on topical bactericidal agents .
Cat. No.: HY-W237019
CAS No.: 55836-69-6
3-Ethoxybenzamide is an alkoxybenzamide compound with antibacterial activity and a FtsZ inhibitor that can cross the blood-brain barrier. 3-Ethoxybenzamide distributes widely and rapidly in vivo, rapidly reaches equilibrium between various tissues and blood, and is linearly taken up by hepatocytes. 3-Ethoxybenzamide is completely dependent on hepatic microsomal oxidation for clearance, with salicylamide as its major metabolite. 3-Ethoxybenzamide can be used for the study of bacterial infections .
Cat. No.: HY-180273
Antibacterial agent 309 (Compound C9) is an antibacterial agent, substrate of AcrB efflux pump. Antibacterial agent 309 promotes FtsZ polymerization. Antibacterial agent 309 demonstrates antibacterial activity against Erythromycin (HY-B0220)-resistant S. pyogenes 2 (MIC = 0.25 μg/mL), Penicillin-resistant S. aureus CI (MIC = 0.125 μg/mL), Penicillin-resistant S. epidermidis (MIC = 2 μg/mL). Antibacterial agent 309 exhibits weak antibacterial activity against the wild-type E. coli BW25113 MIC = 256 μg/mL) .
Cat. No.: HY-126051
CAS No.: 1381782-08-6
Synonyms: (-)-Viriditoxin
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
