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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
ITK
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "ITK" in MCE Product Catalog:
Cat. No.: HY-146671
CAS No.: 2404603-41-2
ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC50s of 5.6, 25 nM for ITK, BTK, respectively .
Cat. No.: HY-146672
CAS No.: 2404604-06-2
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities .
Cat. No.: HY-141864
CAS No.: 2655557-54-1
Target:
Research Areas:
ITK/TRKA-IN-1 is a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA) with an IC50 value of 1.0 nM and 96 % inhibition, respectively.
Cat. No.: HY-185206
CAS No.: 2756388-01-7
BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the NF-κB/GATA-3 signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma .
Cat. No.: HY-168963
PROTAC BTK Degrader-13 is a reagent targeting BTK, with a DC50 of 0.27 μM. PROTAC BTK Degrader-13 degrades BTK in a proteasome-dependent manner and inhibits BTK-mediated downstream signaling pathways by reducing the phosphorylation levels of BTK and p38 MAPK. PROTAC BTK Degrader-13 exerts selective cytotoxic effects on BTK-overexpressing lymphoma cells and ITK-positive cells. PROTAC BTK Degrader-13 can be used in studies related to B-cell lymphoma .
Cat. No.: HY-168387
Research Areas:
ITK ligand 1 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). ITK ligand 1 can be used in the synthesis of PROTACs (e.g. HY-149917) .
Cat. No.: HY-RS06979
Target:
Research Areas:
ITK Human Pre-designed siRNA Set A contains three designed siRNAs for ITK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06980
Target:
Research Areas:
Itk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06981
Target:
Research Areas:
Itk Rat Pre-designed siRNA Set A contains three designed siRNAs for Itk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-143900
CAS No.: 2952702-39-3
Research Areas:
BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM). BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold). BTK-IN-7 also has potent antitumor activity .
Cat. No.: HY-110113
CAS No.: 1265822-30-7
CTA056 is an ITK (IL-2-inducible T-cell kinase) inhibitor with an IC50 of 0.1 μM. CTA056 selectively targets malignant T cells and modulates oncomirs. CTA056 induces apoptosis and is a potential therapeutic agent for the research of T-cell leukemia and lymphoma .
Cat. No.: HY-184275
CAS No.: 3126105-55-0
ITK-IN-7 is a selective ITK inhibitor with an IC50 of 16 nM and a Ki of 0.48 nM. ITK-IN-7 reduces IL-2 secretion levels in T cells and in mouse models stimulated by anti-CD3 monoclonal antibodies. ITK-IN-7 can be used for basic and translational research related to ITK inhibition, such as research on leukemia .
Cat. No.: HY-P74795
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ITK; T-Cell-Specific Kinase; IL2 Inducible T Cell Kinase; Kinase EMT; EMT; Homolog Of Mouse T-Cell ITK/Tsk; LYK; IL2-Inducible T-Cell Kinase; PSCTK2; IL2 Inducible T-Cell Kinase; Interleukin-2-Inducible T-Cell Kinase; Tyrosine-Protein Kinase LYK; Tyrosine-Protein Kinase ITK/TSK; Tyrosine-Protein Kinase Lyk; IL-2-Inducible T-Cell Kinase; LPFS1
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P705930
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ITK; T-Cell-Specific Kinase; IL2 Inducible T Cell Kinase; Kinase EMT; EMT; Homolog Of Mouse T-Cell ITK/Tsk; LYK; IL2-Inducible T-Cell Kinase; PSCTK2; IL2 Inducible T-Cell Kinase; Interleukin-2-Inducible T-Cell Kinase; Tyrosine-Protein Kinase LYK; Tyrosine
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
