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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
Noxa
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "Noxa" in MCE Product Catalog:
Cat. No.: HY-126324
CAS No.: 2326007-49-0
IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC) .
Cat. No.: HY-RS28184
Target:
Research Areas:
Noxa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Noxa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15676R
CAS No.: 1229705-06-9
Synonyms: RG7388 (Standard)
Idasanutlin (Standard) (RG7388 (Standard)) is the analytical standard of Idasanutlin (HY-15676). This product is intended for research and analytical applications. Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC50 of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors .
Cat. No.: HY-P82808A
Synonyms: APR; ATL-derived; Noxa; Pmaip1; Protein Noxa
Cat. No.: HY-RS20580
Target:
Research Areas:
Pmaip1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pmaip1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P810353
Synonyms: Adult T cell leukemia derived PMA responsive, APR, APR_HUMAN, ATL-derived, Immediate early response protein APR, Immediate-early-response protein APR, Noxa, Phorbol 12 myristate 13 acetate induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA induced protein 1
Cat. No.: HY-119408
CAS No.: 2230058-99-6
Target:
Research Areas:
MB725 is an ethylamide analogue of MB710 (HY-120373). MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer .
Cat. No.: HY-110078R
CAS No.: 412960-54-4
Target:
Research Areas:
Eeyarestatin I (Standard) is the analytical standard of Eeyarestatin I (HY-110078). This product is intended for research and analytical applications. Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
Cat. No.: HY-129179S
Synonyms: APG-2575-d8; Bcl-2/Bcl-xl inhibitor 1-d8
Target:
Research Areas:
Lisaftoclax-d8 is the deuterated-labeled Lisaftoclax (HY-129179). Lisaftoclax is an orally active, selective BCL-2 inhibitor with a Ki of < 0.1 nM against human BCL-2. Lisaftoclax selectively binds to BCL-2, disrupts the BCL-2:BIM complex, and antagonizes the antiapoptotic function of BCL-2. Lisaftoclax induces BAX/BAK-dependent, caspase-mediated apoptosis, upregulates the pro-death proteins BIM and Noxa, and downregulates mitochondrial respiratory function and ATP production. Lisaftoclax can be used in the research of hematological malignancies including chronic lymphocytic leukemia, multiple myeloma, and diffuse large B-cell lymphoma .
Cat. No.: HY-180820
Research Areas:
Dimethyl bisphenolate (Compound DMB) is a natural neolignan derivative with orally active anti-tumor activity. Dimethyl bisphenolate can inhibit cancer cells proliferation, invasion and migration. Dimethyl bisphenolate can activate the p53 signaling pathway, upregulate the expression of p21 protein, inhibit the activity of the CDK1-cyclin B1 complex, and cause cells to stall at the G2/M phase. Dimethyl bisphenolate can induce ROS production, upregulate pro-apoptotic proteins Noxa and Bim, downregulate anti-apoptotic protein Bcl-2, activate caspase-9 and caspase-3, and ultimately induce cell apoptosis. Dimethyl bisphenolate can be used for research of glioblastoma .
Cat. No.: HY-P74656
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NCF2; Chronic Granulomatous Disease, Autosomal 2; Neutrophil Cytosolic Factor 2; 67 KDa Neutrophil Oxidase Factor; Noxa2; NCF-2; Neutrophil NADPH Oxidase Factor 2; Neutrophil Cytosolic Factor 2 Isoform 3; Neutrophil Cytosol Factor 2; P67-PHOX; NADPH Oxida
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P74655
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NCF2; Chronic Granulomatous Disease, Autosomal 2; Neutrophil Cytosolic Factor 2; 67 KDa Neutrophil Oxidase Factor; Noxa2; NCF-2; Neutrophil NADPH Oxidase Factor 2; Neutrophil Cytosolic Factor 2 Isoform 3; Neutrophil Cytosol Factor 2; P67-PHOX; NADPH Oxida
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-N0660R
CAS No.: 55466-05-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
