Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
OVCaR-3
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "OVCaR-3" in MCE Product Catalog:
Cat. No.: HY-168180
CAS No.: 2975172-98-4
WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC50 of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC50s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively .
Cat. No.: HY-164979
CAS No.: 3051552-64-5
KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies .
Cat. No.: HY-N10922
CAS No.: 878800-84-1
Target:
Cat. No.: HY-N16507
CAS No.: 167782-22-1
Target:
Cat. No.: HY-182791
BAA-009 is a selective and orally active PKMYT1 inhibitor with an IC50 of <50 nM. BAA-009 inhibits cancer cells proliferation and inhibits tumor growth in OVCAR3 xenograft mice. BAA-009 can be used for the research of cancer, such as ovarian cancer .
Cat. No.: HY-N15345
Category:
Target:
Cat. No.: HY-182790
BAA-065 is a selective and orally active PKMYT1 inhibitor with an IC50 of <50 nM. BAA-065 inhibits cancer cells proliferation, induces γH2AX expression and DNA damage. BAA-065 inhibits tumor growth in OVCAR3 xenograft mice. BAA-065 can be used for the research of cancer, such as ovarian cancer .
Cat. No.: HY-189647
CAS No.: 3120750-94-6
KIF18A-IN-20 is an orally active KIF18A inhibitor with an IC50 of 52 nM. KIF18A-IN-20 targets the plus-end-directed mitotic kinesin KIF18A, regulating chromosome alignment and spindle dynamics, and inhibits the proliferation of chromosomally unstable OVCAR-3 ovarian cancer cells with EC50 = 3.4 nM. KIF18A-IN-20 achieves tumor regression in xenograft models without causing body weight loss. KIF18A-IN-20 can be used for research related to ovarian cancer .
Cat. No.: HY-176957
CAS No.: 3097325-25-9
PKMYT1-IN-11 (Example 1) is a PKMYT1 inhibitor with an IC50 of 4.49 nM. PKMYT1-IN-11 inhibits the proliferation of HCC1569 cells. When combined with Gemcitabine (HY-17026), PKMYT1-IN-11 shows a significant anti-tumor effect in the OVCAR3 xenograft mouse model. PKMYT1-IN-11 can be used for the study of various cancers such as breast cancer and ovarian cancer .
Cat. No.: HY-187562
PKMYT1-IN-15 is an orally active PKMYT1 inhibitor with an IC50 of 6.02 nM. PKMYT1-IN-15 inhibits the phosphorylation of CDK1 at Thr14. As an antiproliferative agent, DNA damage inducer and antitumor agent, PKMYT1-IN-15 triggers replication-associated DNA damage and cell death in CCNE1-amplified cancer cells, and suppresses tumor growth in the OVCAR3 xenograft model. PKMYT1-IN-15 can be used for the research of CCNE1-amplified cancers (e.g., ovarian cancer, breast cancer) .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
