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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
254 Results for "
concentration-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (254)
254 Results for "concentration-dependent" in MCE Product Catalog:
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Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .
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Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus wallichiana Zucc.
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1 Cited Publications
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PROTAC CYP1B1 degrader-1 is a CYP1B1 PROTAC degrader with a human IC50 of 95.1 nM. PROTAC CYP1B1 degrader-1 induces concentration-dependent CYP1B1 degradation. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-mediated Docetaxel (HY-B0011)-resistant prostate cancer .
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1 Cited Publications
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ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently .
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1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
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Oxybutynin is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM . Oxybutynin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P1236
CAS No.: 88898-17-3
Synonyms: Atrial natriuretic factor (1-28) (rat, mouse)
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Cat. No.: HY-B2133
CAS No.: 14984-68-0
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Cloperastine hydrochloride inhibits the hERG K + currents in a concentration-dependent manner with an IC50 value of 27 nM .
Cat. No.: HY-W004784
CAS No.: 2345-51-9
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Cat. No.: HY-N7066
CAS No.: 91296-86-5
Synonyms: A-56619 hydrochloride
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Difloxacin hydrochloride (A-56619 hydrochloride) is an orally active bactericidal agent. Difloxacin hydrochloride inhibits bacterial DNA gyrase. Difloxacin hydrochloride exhibits concentration-dependent bactericidal activity. Difloxacin hydrochloride shows strong in vitro activity against a variety of Gram-positive and Gram-negative bacteria. Difloxacin hydrochloride can be used in research related to colibacillosis and *Staphylococcus aureus* infections .
Cat. No.: HY-B2179
CAS No.: 85187-37-7
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Cloperastine fendizoate inhibits the hERG K + currents in a concentration-dependent manner with an IC50 value of 27 nM.
Cat. No.: HY-P1236A
Synonyms: Atrial natriuretic factor (1-28) (rat, mouse) TFA
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Synonyms: BIA 5-1058
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Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively . Zamicastat reduces high blood pressure .
Cat. No.: HY-N10117
CAS No.: 138250-72-3
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Alkaloids Hordeum vulgare var. coeleste Linnaeus Gramineae Other Diseases Plants Disease Research Fields Indole Alkaloids
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Synonyms: Methoxyverapamil hydrochloride
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Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist . Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM . Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent .
Cat. No.: HY-77537
CAS No.: 39929-79-8
Synonyms: 7DX
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7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect .
Cat. No.: HY-160259
CAS No.: 2353417-86-2
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VEGFR-2-IN-39 (PROTAC-5) is a PROTAC targeting VEGFR-2 (IC50: 208.6 nM). VEGFR-2-IN-39 has low toxicity.VEGFR-2-IN-39 inhibits the proliferation of EA.hy926, one of HUVECs, in a concentration-dependent manner, with an IC50 of 38.65 µM .
Cat. No.: HY-W015343
CAS No.: 1798-09-0
Synonyms: m-Methoxyphenylacetic acid
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Cat. No.: HY-U00027
CAS No.: 101193-62-8
Synonyms: FR71021
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Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
