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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
beta-sheet
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "beta-sheet" in MCE Product Catalog:
Referencia número: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
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Referencia número: HY-P4882
No. CAS: 183449-57-2
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Referencia número: HY-P11309
No. CAS: 957365-81-0
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Referencia número: HY-P4370
No. CAS: 342790-23-2
Referencia número: HY-P10699
No. CAS: 487036-63-5
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Referencia número: HY-P4873
No. CAS: 118068-30-7
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Referencia número: HY-114884
No. CAS: 530112-00-6
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RS-0406 is a beta-sheet breaker targeting Amyloid-β. RS-0406 can inhibits Aβ(1-42) fibrillogenesis and protect against Aβ(1-42)-induced cytotoxicity in primary hippocampal neurons. RS-0406 can be used for the research of neurological disease, such as Alzheimer's disease (AD) .
Referencia número: HY-P10155
No. CAS: 352653-12-4
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Referencia número: HY-P5340
No. CAS: 339091-39-3
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Referencia número: HY-P11231
No. CAS: 2780353-11-7
Synonyms: FUS(364-369)-TAT
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Referencia número: HY-P5515
No. CAS: 409085-40-1
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Referencia número: HY-P5967
No. CAS: 189064-06-0
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Referencia número: HY-P10534
No. CAS: 873582-78-6
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ccβ is a 17-residue peptide that folds into a coiled-coil trimer at low temperatures and aggregates to form amyloid fibrils at high temperatures. ccβ serves as a simple model system for investigating α-helix to β-sheet conformational transitions and template-mediated aggregation processes associated with prion and amyloidogenic diseases. ccβ can be used in studies of prion diseases and Alzheimer's disease .
Referencia número: HY-P5906
Synonyms: Citrullinated Aβ (1-40); Citrullinated Aβ40
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Referencia número: HY-149509
No. CAS: 1510825-03-2
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α-Synuclein inhibitor 9 (Compound 20C) is an α-Synuclein inhibitor. α-Synuclein inhibitor 9 binds to cavities in mature α-synuclein fibrils and reduces the β-sheet structure. α-Synuclein inhibitor 9 inhibits A53T α-Syn aggregation. α-Synuclein inhibitor 9 has neuroprotective effect, improves brain functional connection and relieves motor dysfunction.α-Synuclein inhibitor 9 can be used for Parkinson’s disease (PD) research. .
Referencia número: HY-13325
No. CAS: 71939-12-3
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Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD) .
Referencia número: HY-P5917
No. CAS: 1373890-79-9
Synonyms: Vaejovis mexicanus peptide 24
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Referencia número: HY-P1889A
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Bim BH3, Peptide IV TFA is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV TFA binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV TFA modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV TFA promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV TFA enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV TFA induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV TFA can be used for research on Alzheimer's disease .
Referencia número: HY-P12350
No. CAS: 1261043-80-4
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Ac-I3K-NH2 is a surfactant-like peptide. Ac-I3K-NH2 self-assembles into β-sheet nanofibers through β-sheet hydrogen bonding, hydrophobic interactions, and electrostatic repulsion. Ac-I3K-NH2 forms ribbon-like nanofibers with nanoscale widths, adopting a β-sheet conformation, with lateral stacking driven by isoleucine side-chain contacts. Ac-I3K-NH2 templates the sol-gel condensation of tetraethoxysilane, producing silica nanotubes. Ac-I3K-NH2 templates the synthesis of one-dimensional Pt nanostructures with P7A as a capping agent .
Referencia número: HY-161658
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N-Caffeoyldopamine (Compound 6i) is an amyloid-beta aggregation inhibitor. N-Caffeoyldopamine can inhibit Aβ aggregation to form nano-rod-like structures, thereby preventing β-sheet formation. N-Caffeoyldopamine can be used for Alzheimer's disease research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
