145 Results for "

inflammatory component

" in MedChemExpress (MCE) Product Catalog:

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Cinnamyl Alcohol

2 Cited Publications

Cat. No.: HY-Y0078

CAS No.: 104-54-1

Category:

Simple Phenylpropanols Metabolic Disease Phenylpropanoids Plants Fagaceae Disease Research Fields Croton poilanei Gagnep.

Target:

Environmental Pollutants AMPK ERK Potassium Channel Akt ROCK NO Synthase PPAR

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities .

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Araloside A

2 Cited Publications

Cat. No.: HY-N2115

CAS No.: 7518-22-1

Synonyms: Chikusetsusaponin IV

Category:

Cardiovascular Disease Triterpenes other families Terpenoids Plants Disease Research Fields Araliaceae

Target:

Renin Apoptosis Bcl-2 Family Interleukin Related

Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

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Cucurbitacin IIb

2 Cited Publications

Cat. No.: HY-N1987

CAS No.: 50298-90-3

Category:

Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Inflammation/Immunology Hemsleya amabilis Diels

Target:

Apoptosis

Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

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D-Glucuronic acid

1 Cited Publications

Cat. No.: HY-N6612

CAS No.: 6556-12-3

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite Toll-like Receptor (TLR)

D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity .

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5,7-Dimethoxyflavone

1 Cited Publications

Cat. No.: HY-N5011

CAS No.: 21392-57-4

Category:

Flavonoids Flavones Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Inflammation/Immunology Cancer Zingiberaceae

Target:

Cytochrome P450

5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor .

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Linalyl acetate

1 Cited Publications

Cat. No.: HY-N6948

CAS No.: 115-95-7

Category:

Natural Products Labiatae Plants Dolichos trilobus Houtt. Disease Research Fields Inflammation/Immunology

Target:

Environmental Pollutants Lactate Dehydrogenase

Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

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Cimifugin

1 Cited Publications

Cat. No.: HY-N0634

CAS No.: 37921-38-3

Synonyms: Cimitin

Category:

Ranunculaceae Coumarins Phenylpropanoids Plants Cimicifuga racemosa (L.) Nutt. Disease Research Fields Inflammation/Immunology

Target:

NF-κB

Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions . Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS .

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Chelidonic acid

1 Cited Publications

Cat. No.: HY-W041489

CAS No.: 99-32-1

Category:

Chelidonium majus Ketones, Aldehydes, Acids Plants Disease Research Fields Papaveraceae Cancer

Target:

NF-κB Caspase

Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

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Soyasapogenol B

1 Cited Publications

Cat. No.: HY-N6074

CAS No.: 595-15-3

Category:

Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Plants Disease Research Fields Cancer

Target:

Autophagy Apoptosis

Soyasapogenol B is a component of soy that has oral activity. Soyasapogenol B promotes autophagy and apoptosis. Soyasapogenol B has anti-inflammatory, antioxidant and antitumor activities .

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Benzoylmesaconine

1 Cited Publications

Cat. No.: HY-N0218

CAS No.: 63238-67-5

Synonyms: Mesaconine 14-benzoate

Category:

Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Inflammation/Immunology

Target:

NF-κB Interleukin Related

Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress NLRP3 inflammasome activation by inhibiting IL-1β secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K ⁺ efflux and disrupts NLRP3 inflammasome assembly .

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3-Epioleanolic acid

1 Cited Publications

Cat. No.: HY-N4290

CAS No.: 25499-90-5

Category:

Triterpenes other families Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:

Others

3-Epioleanolic acid is an active component of Verbena officinalis Linn, with anti-inflammatory activity .

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Flutrimazole

1 Cited Publications

Cat. No.: HY-129060

CAS No.: 119006-77-8

Pureté: 99.34%

Target:

Fungal

Domaines de recherche:

Infection

Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component .

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D-Glucuronic acid sodium salt monohydrate

1 Cited Publications

Cat. No.: HY-N6612A

CAS No.: 207300-70-7

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Toll-like Receptor (TLR)

D-Glucuronic acid sodium salt monohydrate is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid sodium salt monohydrate activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid sodium salt monohydrate and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity .

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Cuminaldehyde

1 Cited Publications

Cat. No.: HY-Y0790

CAS No.: 122-03-2

Synonyms: p-Isopropylbenzaldehyde

Category:

Rudbeckia laciniata L. Ketones, Aldehydes, Acids Plants Umbelliferae Endogenous metabolite Disease Research Fields Cancer

Target:

Environmental Pollutants α-synuclein

Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

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Schisantherin B

1 Cited Publications

Cat. No.: HY-N0695

CAS No.: 58546-55-7

Synonyms: Gomisin-B; Wuweizi ester-B; Schisantherin-B

Category:

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:

PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis

Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .

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Docosapentaenoic acid (22n-3)

Cat. No.: HY-113159

CAS No.: 24880-45-3

Pureté: 99.87%

Synonyms: Clupanodonic acid

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields

Target:

Amylases Glycosidase

Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect .

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N-Acetylmuramic acid

Cat. No.: HY-W009274

CAS No.: 10597-89-4

Synonyms: MurNAc; NAMA

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

p38 MAPK NF-κB Bacterial

N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity . N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme . N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape . N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active .

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Myristicin

Cat. No.: HY-N2510

CAS No.: 607-91-0

Synonyms: Myristicine

Category:

Simple Phenylpropanols Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.

Target:

5-HT Receptor EGFR ERK Apoptosis Bacterial

Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

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(R)-(+)-Citronellal

Cat. No.: HY-111664

CAS No.: 2385-77-5

Pureté: 98.72%

Synonyms: (+)-Citronellal

Category:

Other Monoterpenes Citrus limon (L.) Burm. F. Terpenoids Rutaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Citrus reticulata Blanco

Target:

Bacterial Fungal Insecticide Taste Receptor Opioid Receptor

(R)-(+)-Citronellal ((+)-Citronellal) is a monoterpenoid compound and is one of the main components of essential oils from plants such as lemon grass. (R)-(+)-Citronellal has antibacterial, antifungal, and insecticidal activities. (R)-(+)-Citronellal alleviates the bitterness of caffeine by antagonizing the bitter taste receptors Tas2r43 (IC₅₀ = 84 μM) and Tas2R46. (R)-(+)-Citronellal generates analgesic activity by activating the opioid receptor (broad-spectrum opioid receptor) pathway, and its effect is particularly significant for inflammatory pain .

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Menthone

Cat. No.: HY-N2381

CAS No.: 10458-14-7

Category:

Infection Other Monoterpenes Labiatae Terpenoids Erythrina poeppigiana Plants Disease Research Fields Inflammation/Immunology

Target:

NF-κB Parasite

Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis .

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