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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
504 Results for "
CDC
" in MedChemExpress (MCE) Product Catalog:
Products (504)
504 Results for "CDC" in MCE Product Catalog:
Cat. No.: HY-175261
Target:
Research Areas:
DHI1 is an anti-leukemia agent with high selectivity for Jurkat (IC50 = 21.83 μM) and HL-60 (IC50 = 19.14 μM) leukemia cells and has low toxicity to non-cancerous cells. DHI1 can induce G2/M phase cell arrest in Jurkat and HL-60 leukemia cells, as well as S phase arrest in HL-60 cells, and has significant effects on cell cycle signaling molecules Wee1, cyclin B1, cdc2 on Tyr15, and Chk1. DHI1 inhibits the migration and invasion of Jurkat and HL-60 cells by disrupting cytoskeletal actin filaments. DHI1 can be used to study hematological malignancies .
Cat. No.: HY-179177
CAS No.: 1081122-55-5
Target:
Research Areas:
AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor (IC50 = 0.29 μM) and shows a significant inhibitory effect on (CDC-like kinase 1) CLK1 (IC50 = 0.08 μM). AO-365/43472821 could protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid (HY-N6785) (OA)-induced injury. AO-365/43472821 decreased tau (pSer396)/tau and Aβ1-42 protein expression. AO-365/43472821 can be used for the study of Alzheimer's disease .
Cat. No.: HY-182285
CAS No.: 3122097-27-9
Research Areas:
5-HT7 modulator-1 is a selective 5-HT7 receptor antagonist with a Ki of 92 nM. 5-HT7 modulator-1 blocks 5-HT7 receptor signaling to reduce FOXM1, phosphorylated FOXM1, cyclin B1, and cdc25B levels. 5-HT7 modulator-1 acts as an antiproliferative, clonogenic inhibitor, and cell cycle inhibitor that induces G2/M arrest, reduces G0/G1 population. 5-HT7 modulator-1 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-182285A
Target:
Research Areas:
5-HT7 modulator-1 hydrochloride is a selective 5-HT7 receptor antagonist with a Ki of 92 nM. 5-HT7 modulator-1 hydrochloride blocks 5-HT7 receptor signaling to reduce FOXM1, phosphorylated FOXM1, cyclin B1, and cdc25B levels. 5-HT7 modulator-1 hydrochloride acts as an antiproliferative, clonogenic inhibitor, and cell cycle inhibitor that induces G2/M arrest, reduces G0/G1 population. 5-HT7 modulator-1 hydrochloride can be used for the research of triple-negative breast cancer .
Cat. No.: HY-181076
FOXM1-IN-3 is a potent FOXM1 inhibitor. FOXM1-IN-3 downregulates FOXM1 expression at protein and mRNA levels, suppressing downstream effectors CCNB1 and CDC25. FOXM1-IN-3 induces G2/M cell cycle arrest and apoptosis in colorectal cancer cells. FOXM1-IN-3 inhibits colony formation and cell migration in colorectal cancer cells. FOXM1-IN-3 targets the cancer stem cell phenotype in colorectal cancer cells, reducing cancer stem cell marker expression. FOXM1-IN-3 reduces tumor growth in a zebrafish xenograft model. FOXM1-IN-3 can be used for the research of colorectal cancer .
Cat. No.: HY-P991425
Target:
Research Areas:
Cat. No.: HY-P87922
Synonyms: CDC2L4, TAK, CDK9, Cyclin-dependent kinase 9, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit
Cat. No.: HY-P70014
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDK2; CDKN2; Cyclin Dependent Kinase 2; CDC2-Related Protein Kinase; Cell Division Protein Kinase 2; Cyclin-Dependent Kinase; Cyclin-Dependent Kinase 2; P33(CDK2); P33 Protein Kinase
Species:
Human
Source:
E. coli
Cat. No.: HY-P705508
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: VCP; Valosin Containing Protein; Transitional Endoplasmic Reticulum ATPase; 15S Mg(2+)-ATPase P97 Subunit; Valosin-Containing Protein; CDC48; TERA; P97; TER ATPase; IBMPFD; Vesicle-Fusing ATPase; VCP Protein; HEL-S-70; FTDALS6; HEL-220
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705800
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK2; CDKN2; Cyclin Dependent Kinase 2; CDC2-Related Protein Kinase; Cell Division Protein Kinase 2; Cyclin-Dependent Kinase; Cyclin-Dependent Kinase 2; P33(CDK2); P33 Protein Kinase
Species:
Human
Source:
sf9 insect cells
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .
Cat. No.: HY-172085
CAS No.: 3099543-90-2
Target:
Research Areas:
SH514 is an orally active IRF4 inhibitor (IC50 = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors .
Cat. No.: HY-P705801
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK2; CDKN2; Cyclin Dependent Kinase 2; CDC2-Related Protein Kinase; Cell Division Protein Kinase 2; Cyclin-Dependent Kinase; Cyclin-Dependent Kinase 2; P33(CDK2); P33 Protein Kinase
Species:
Human
Source:
E. coli
Cat. No.: HY-P703602
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PKMYT1; Myt1 Kinase; Protein Kinase, Membrane Associated Tyrosine/Threonine 1; PPP1R126; Membrane-Associated Tyrosine- And Threonine-Specific CDC2-Inhibitory Kinase; Protein Phosphatase 1, Regulatory Subunit 126; MYT1; Non-Specific Serine/Threonine Protei
Species:
Human
Source:
E. coli
Cat. No.: HY-P85098
Synonyms: CDK9; CDC2L4; TAK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit
Cat. No.: HY-17539
CAS No.: 1421919-75-6
Research Areas:
KPT-276 is an orally active and blood-brain barrier-penetrant selective XPO1/CRM1 inhibitor. KPT-276 blocks XPO1-mediated nuclear export function and promotes nuclear retention of various tumor suppressor proteins. KPT-276 induces apoptosis and G1 cell cycle arrest in tumor cells, and downregulates c-MYC, CDC25A, and BRD4. KPT-276 reduces immune cell proliferation through nuclear accumulation of cell cycle inhibitors, rescues TDP-43 cytoplasmic mislocalization, and restores axon growth and growth rate in mutant PFN1 motor neurons. KPT-276 maintains axonal cytoskeletal integrity and mitochondrial function, and inhibits tumor growth. KPT-276 can be used for research on glioblastoma, non-Hodgkin lymphoma, amyotrophic lateral sclerosis, multiple myeloma, and non-small cell lung cancer .
Cat. No.: HY-P70981
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: STN1; STN1, CST Complex Subunit; Prev. OBFC1; Replication Protein A 32 KDa Subunit; Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1; Alpha Accessory Factor 44; Suppressor Of CDC Thirteen Homolog; RPA-32; CST Complex Subunit STN1; CRMCC2
Species:
Human
Source:
E. coli
Cat. No.: HY-P702926
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PKMYT1; Myt1 Kinase; Protein Kinase, Membrane Associated Tyrosine/Threonine 1; PPP1R126; Membrane-Associated Tyrosine- And Threonine-Specific CDC2-Inhibitory Kinase; Protein Phosphatase 1, Regulatory Subunit 126; MYT1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P87028
Synonyms: KIAA1142 antibody; p21 activated kinase 4 antibody; p21 CDC42/Rac1-actiated kinase 4 antibody; P21 protein (CDC42/Rac) activated kinase 4 antibody; p21(CDKN1A) activated kinase 4 antibody; p21-activated kinase 4 antibody; PAK 4 antibody; PAK-4 antibody; Pak4 antibody; PAK4_HUMAN antibody; KIAA1142 antibody; p21 activated kinase 4 antibody; p21 CDC42/Rac1-actiated kinase 4 antibody; P21 protein (CDC42/Rac) activated kinase 4 antibody; p21(CDKN1A) activated kinase 4 antibody; p21-activated kinase 4 antibody; PAK 4 antibody; PAK-4 antibody; Pak4 antibody; PAK4_HUMAN antibody; Protein kinase related to S.cerevisiae STE20 effector for CDC42Hs antibody; Serine threonine kinase PAK 4 antibody; Serine/threonine protein kinase PAK 4 antibody; Serine/threonine protein kinase PAK4 antibody; Serine/threonine-protein kinase PAK 4 antibody; EC 2.7.11.1 antibody; KIAA1264 antibody; MGC26232 antibody; p21 activated kinase 7 antibody; p21 protein (CDC42/Rac)-activated kinase 7 antibody; p21(CDKN1A) activated kinase 7 antibody; p21-activated kinase 5 antibody; p21-activated kinase 7 antibody; PAK 5 antibody; PAK 7 antibody; PAK-5 antibody; PAK-7 antibody; PAK5 antibody; PAK7 antibody; PAK7_HUMAN antibody; Protein kinase PAK5 antibody; Serine/threonine protein kinase PAK 7 antibody; Serine/threonine-protein kinase PAK 7 antibody; CDKN1A activated kinase 6 antibody; EC 2.7.1.37 antibody; p21 activated protein kinase 6 antibody; p21 protein (CDC42/Rac)-activated kinase 6 antibody; p21(CDKN1A) activated kinase 6 antibody; p21-activated kinase 6 antibody; p21activated kinase 6 antibody; PAK 6 antibody; PAK-6 antibody; Pak6 antibody; PAK6_HUMAN antibody; Serine threonine protein kinase PAK 6 antibody; Serine/threonine protein kinase PAK 6 antibody; Serine/threonine protein kinase PAK6 antibody; Serine/threonine-protein kinase PAK 6 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
