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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
552 Results for "
electron
" in MedChemExpress (MCE) Product Catalog:
Products (552)
552 Results for "electron" in MCE Product Catalog:
Cat. No.: HY-N21828
CAS No.: 129212-94-8
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Cat. No.: HY-W250154
CAS No.: 104809-32-7
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Cat. No.: HY-113232S
CAS No.: 1276197-31-9
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3-Methylcrotonylglycine-d2 is the deuterated-labeled 3-Methylcrotonylglycine (HY-113232). 3-Methylcrotonylglycine is an organic acid conjugate associated with leucine catabolism that inhibits respiratory chain complex II-III, mitochondrial creatine kinase, and synaptic membrane Na +, K +-ATPase. 3-Methylcrotonylglycine increases reactive oxygen species levels to mediate oxidative damage, while inhibiting mitochondrial electron transport, reducing tricarboxylic acid cycle flux, and interfering with intracellular energy transport and neuronal ion homeostasis. 3-Methylcrotonylglycine is a neurotoxic metabolite that accumulates in the metabolic pathway of 3-methylcrotonyl-CoA carboxylase deficiency. 3-Methylcrotonylglycine can be used in studies related to 3-methylcrotonyl-CoA carboxylase deficiency .
Synonyms: JF646, Tetrazine
Cat. No.: HY-181286
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ETX1975-3 is an orally active inhibitor and bactericide targeting the bd cytochrome oxidase of Mycobacterium tuberculosis. ETX1975-3 disrupts electron transfer between the b-heme centers of the target enzyme, and in combination with Q203 (HY-101040), exerts bactericidal activity against both replicating and non-replicating Mycobacterium tuberculosis, and reduces bacterial loads in acute mouse models. ETX1975-3 retains activity against clinical isolates of multidrug-resistant/extensively drug-resistant Mycobacterium tuberculosis and non-tuberculous mycobacteria, while possessing favorable preclinical ADMET properties. ETX1975-3 can be used in studies related to tuberculosis and non-tuberculous mycobacterial infections .
Cat. No.: HY-D1450
CAS No.: 155613-98-2
Synonyms: S01448
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IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment .
Cat. No.: HY-D3351
CAS No.: 2668963-61-7
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PNO1 is a fluorescent probe for pulmonary fibrosis detection. The detection mechanism of PNO1 relies on sensing upregulated nitric oxide (NO) in the pulmonary fibrosis (PF) microenvironment. PNO1 contains an aniline group that reacts with NO or its derivatives under acidic conditions to form an N-nitrosylated intermediate, which is subsequently converted into a diazonium salt and undergoes deamination, eliminating the intramolecular electron transfer quenching effect and triggering a fluorescence turn-on response. The excitation wavelength of PNO1 includes 545 nm in in vitro solution studies, while an excitation range of 520-550 nm is used for cell, tissue and in vivo imaging; its emission wavelength centers at 572 nm in the unreacted state, and shifts to 559 nm with enhanced fluorescence intensity upon binding to NO. PNO1 can be used for pulmonary fibrosis research .
Cat. No.: HY-N7151R
CAS No.: 108354-13-8
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Cat. No.: HY-W251143
CAS No.: 83054-80-2
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N,N′-Bis(2,5-di-tert-butylphenyl)-3,4,9,10-perylenedicarboximide is an organic semiconductor material with excellent electron transport activity. N,N′-Bis(2,5-di-tert-butylphenyl)-3,4,9,10-perylenedicarboximide is widely used in organic field effect transistors (OFETs) and organic photovoltaic (OPV) devices due to its high carrier mobility. The chemical structure design of N,N′-Bis(2,5-di-tert-butylphenyl)-3,4,9,10-perylenedicarboximide enables it to perform well in light absorption and photoelectric conversion, thereby improving the efficiency of organic photoelectric devices.
Cat. No.: HY-W251144
CAS No.: 76372-75-3
Synonyms: PTCDI-C5
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N,N′-Dipentyl-3,4,9,10-perylenedicarboximide (PTCDI-C5) is an organic semiconductor compound with excellent electron transport activity. N,N′-Dipentyl-3,4,9,10-perylenedicarboximide exhibits high performance in organic field effect transistors (OFETs) and can effectively improve the carrier mobility of the device. The application of N,N′-Dipentyl-3,4,9,10-perylenedicarboximide in organic photovoltaic (OPV) materials enhances the light absorption performance, thereby improving the photoelectric conversion efficiency. N,N′-Dipentyl-3,4,9,10-perylenedicarboximide has also been widely studied for the development of high-performance sensors and fluorescent materials.
Cat. No.: HY-W778649
CAS No.: 1795136-21-8
Cat. No.: HY-W133963
CAS No.: 9063-38-1
Cat. No.: HY-182341
CAS No.: 1261156-82-4
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APD-209 is a sialic acid conjugate with a PEG4 polar linker and a PDA non-polar tail. APD-209 aggregates adenovirus type 37 particles, blocks the binding of viral particles to human corneal epithelial cells, and inhibits cellular entry of adenovirus type 37. APD-209 can be used for the research of epidemic keratoconjunctivitis .
Cat. No.: HY-D0142
CAS No.: 59572-10-0
Cat. No.: HY-D1470
CAS No.: 210832-86-3
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BADAN is a thiol-reactive, environment-sensitive fluorescent probe used for site-specific labeling of protein cysteine residues to detect protein topology, local polarity, protein-lipid interactions, and conformational changes. The bromoacetyl group of BADAN covalently binds to cysteine thiols, and its fluorescence originates from the intramolecular charge transfer (ICT) excited state. The emission peak position varies with the polarity of the surrounding medium: it blue-shifts to approximately 488 nm in nonpolar environments (such as the hydrophobic core of lipid bilayers) and red-shifts to approximately 496-507 nm in polar environments (such as aqueous phases), independent of enzymes, pH, or membrane potential. Ex = 380-402 nm; Em = 400-600 nm .
Cat. No.: HY-N19720
CAS No.: 22684-08-8
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Cat. No.: HY-W014793
CAS No.: 41394-05-2
Metamitron is a triazinone pre-emergence and post-emergence Herbicide and fruit thinner. Metamitron controls broadleaf weeds and grassy weeds. Metamitron induces fruit drop in peach trees, and promotes fruit drop, reduces yield per plant, and increases the proportion of large fruits in apple trees. Metamitron is applicable to research related to the management of broadleaf weeds, grassy weeds, and temperate fruit tree crops .
Cat. No.: HY-W035133
CAS No.: 14527-51-6
Synonyms: 5,10,15,20-Tetra-p-tolyl-21H,23H-porphine
Cat. No.: HY-130509
CAS No.: 81213-52-7
Synonyms: Otmpmms
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MTSSL (Otmpmms) is a highly reactive thiol-specific spin label that can be used to label thiol residues in proteins for the determination of protein structure and dynamics, as well as studies on protein-protein interactions. MTSSL serves as a nitroxide labeling reagent for cysteine residues in recombinant mouse prion protein (moPrP C) mutants. MTSSL can be applied in studies of transmissible spongiform encephalopathies (prion diseases) .
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2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
