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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
55 Results for "
quinoline-based hydrazone
" in MedChemExpress (MCE) Product Catalog:
Products (55)
55 Results for "quinoline-based hydrazone" in MCE Product Catalog:
Cat. No.: HY-179350A
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EG01449 is a quinoline-based antagonist of Neuropilin-1 (NRP1) with an Kd of 0.6 µM. EG01449 competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM. EG01449 prevents VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can be used for the research of nociceptive pain .
Cat. No.: HY-179350
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EG01449 Free acid is a quinoline-based antagonist of Neuropilin-1 (NRP1) with an Kd of 0.6 µM. EG01449 Free acid competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM. EG01449 Free acid prevents VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 Free acid can be used for the research of nociceptive pain .
Cat. No.: HY-167189
CAS No.: 682763-67-3
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BF-158 is a quinoline-based Tau Protein fluorescent imaging probe that produces specific staining by recognizing the β-sheet structure of paired helical filaments (PHF)/neurofibrillary tangles (NFT) in tau aggregates, with EC50 values of 399 nM and 659 nM for tau fibrils and Aβ1-42 fibrils, respectively. BF-158 preferentially labels NFTs, neuropil threads, and PHF-type neurites. BF-158 is useful for the study and imaging of tau pathology in Alzheimer's disease .
Cat. No.: HY-W075519
CAS No.: 13025-99-5
Synonyms: 4-Pyridinecarboxaldehyde isonicotinoyl hydrazone
Cat. No.: HY-W013948S
CAS No.: 259824-53-8
Synonyms: Propanal, (2,4-dinitrophenyl)hydrazone-d3
Cat. No.: HY-161752A
CAS No.: 84889-00-9
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(E)-Antibacterial agent 224 is an isomer of Antibacterial agent 224 (HY-161752). Antibacterial agent 224 is a potent and selective synthetic hydrazone inhibitor against the Salmonella PhoP/PhoQ system .
Cat. No.: HY-W806606
CAS No.: 114578-39-1
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Pent-4-ynehydrazide is an intermediate in organic synthesis. Pent-4-ynehydrazide can be used to synthesize Hydrazone-DOX-Alkyne. Pent-4-yne hydrazide can be used in the research of cancer .
Cat. No.: HY-172285A
Cat. No.: HY-W013677S1
CAS No.: 285977-82-4
Cat. No.: HY-181116
Anticancer agent 298 is a bi-nuclear Cu(II)-hydrazone complexe. Anticancer agent 298 can bind to the CDK-2 active site (PDB ID: 3IG7) via hydrogen bonds with key amino acid residues. Anticancer agent 298 exerts cytotoxic effects against hepatocellular carcinoma cells, and has lower cytotoxicity against normal human embryonic kidney cells. Anticancer agent 298 can be used for the research of hepatocellular carcinoma .
Cat. No.: HY-189286
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Anticancer agent-364 is a phenylalanine-derived hydrazone heterocyclic compound that exhibits selective cytotoxicity against NSCLC lung cancer cells. Anticancer agent-364 inhibits VEGF-A, VEGFR-1, and VEGFR-2, increases caspase-3/7, caspase-8, and caspase-9 activity, and induces apoptosis. Anticancer agent-364 can be used for research on non-small cell lung cancer .
Cat. No.: HY-181923
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IMP-Zn is a pyrazole-hydrazone Schiff base zinc (II) complex. IMP-Zn exhibits significant antiproliferative activity against human colorectal cancer cells and induces cell cycle arrest. IMP-Zn shows stronger binding affinity than its free ligand IMP towards three cancer-related protein targets: EGFR kinase 1M17, cytochrome P450 3RUK, and CDK inhibitor 6GUE. IMP-Zn can be used in studies related to colorectal cancer .
Cat. No.: HY-W009411S
CAS No.: 2108149-00-2
Cat. No.: HY-183549
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Ferroptosis/apoptosis inducer-4 is a pyridine-hydrazone-derived Cu (II) complex and a synergistic inducer of ferroptosis and apoptosis. Ferroptosis/apoptosis inducer-4 exerts anti-tumor proliferation and anti-metastasis effects with extremely low systemic toxicity. Ferroptosis/apoptosis inducer-4 disrupts cellular redox homeostasis by depleting glutathione and generating hydroxyl radicals through the Cu 2+/Cu + redox cycle. Ferroptosis/apoptosis inducer-4 also triggers mitochondrial dysfunction and endoplasmic reticulum stress, which in turn lead to Ca 2+ release, mitochondrial Ca 2+ overload, and the formation of a ROS−Ca 2+ self-amplifying feedback loop. Ferroptosis/apoptosis inducer-4 can be used in studies related to cervical cancer .
Cat. No.: HY-D3190
CAS No.: 2173116-67-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
