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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
655 Results for "
root
" in MedChemExpress (MCE) Product Catalog:
Products (655)
655 Results for "root" in MCE Product Catalog:
Cat. No.: HY-N17336
CAS No.: 36449-99-7
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Cat. No.: HY-120751A
CAS No.: 2751591-42-9
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(S)-TROX-1 is the S-enantiomer of TROX-1 (HY-120751). TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC50 value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain .
Cat. No.: HY-N12486A
CAS No.: 2962060-53-1
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Cat. No.: HY-10402A
CAS No.: 1246654-84-1
Synonyms: GSK-AHAB hydrochloride; GW856553X hydrochloride; SB856553 hydrochloride
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Cardiovascular Disease Infection Neurological Disease Cancer
Losmapimod (GSK-AHAB; GW856553X) hydrochloride is an orally active p38α/β MAPK inhibitor, with pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Losmapimod hydrochloride reduces DUX4 expression, thus exerting efficacy in facioscapulohumeral muscular dystrophy. By inhibiting MAPK/NF-κB, Losmapimod hydrochloride reduces apoptosis of epileptiform hippocampal neurons, and exhibits anti-allodynia and anti-hyperalgesic activities. Losmapimod hydrochloride blocks the entry and fusion of Lassa fever virus (LASV). Losmapimod hydrochloride overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Losmapimod hydrochloride inhibits myocardial senescence and inflammation, and possesses cardioprotective activity against cardiotoxicity .
Cat. No.: HY-10402R
CAS No.: 585543-15-3
Synonyms: GSK-AHAB (Standard); GW856553X (Standard); SB856553 (Standard)
Research Areas:
Cardiovascular Disease Infection Neurological Disease Cancer
Losmapimod (GSK-AHAB; GW856553X) (Standard) is the analytical standard of Losmapimod (HY-10402). This product is intended for research and analytical applications. Losmapimod (GSK-AHAB; GW856553X) is an orally active p38α/β MAPK inhibitor, with pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Losmapimod reduces DUX4 expression, thus exerting efficacy in facioscapulohumeral muscular dystrophy. By inhibiting MAPK/NF-κB, Losmapimod reduces apoptosis of epileptiform hippocampal neurons, and exhibits anti-allodynia and anti-hyperalgesic activities. Losmapimod blocks the entry and fusion of Lassa fever virus (LASV). Losmapimod overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Losmapimod inhibits myocardial senescence and inflammation, and possesses cardioprotective activity against cardiotoxicity .
Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .
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Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons .
Cat. No.: HY-184601
Glycyrrhizic acid (GA) is a saponin derived from the root of the traditional Chinese medicine licorice. It possesses various pharmacological effects, such as anti-inflammatory, antioxidant, immunomodulatory, and antiviral activity. In addition to its own pharmacological activity, GA can form complexes with many drugs and other natural products. Structurally, glycyrrhizic acid is an amphiphilic molecule; its hydrophilic portion consists of glucuronic acid residues, while its hydrophobic portion is composed of glycyrrhizic acid residues. It can aggregate in water to form self-assembled micelles. Glycyrrhizic acid encapsulates hydrophobic drugs through self-assembly into host-guest complexes, thereby increasing drug solubility and inhibiting precipitation. These complexes can also achieve sustained and controlled release of encapsulated drugs. Therefore, glycyrrhizic acid micelles can serve as drug carriers to improve the absorption of hydrophobic drugs.
Cat. No.: HY-N0373R
CAS No.: 58749-23-8
Category:
Microorganisms Gibberellins Other Diseases Rutaceae Plants Phytohormone Disease Research Fields Citrus reticulata Blanco Agricultural Research
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Cat. No.: HY-W116336D
CAS No.: 1314-13-2
Cat. No.: HY-E71366
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Endo-1,4-β-D-glucanase is a glycoside hydrolase that cleaves internal β-1,4-glycosidic bonds in cellulose and related β-D-glucans (β-D-Glucan) (HY-139413). Endo-1,4-β-D-glucanase randomly cuts long, insoluble cellulose polymer chains into shorter, soluble fragments such as oligosaccharides, thereby paving the way for further digestion into glucose .
Cat. No.: HY-N21606
CAS No.: 53823-08-8
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Cat. No.: HY-W115721
CAS No.: 523-21-7
Synonyms: Sodium rhodizonate dibasic
Cat. No.: HY-101241B
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MPPG TFA, phenylglycine analogue, is a potent and selective metabotropic glutamate receptor (mGluR) antagonist with a kD value of 9.2 μM. MPPG TFA antagonizes both L-AP4 (HY-100781A)- and (1 S,3S)-ACPD-induced depressions of the monosynaptic excitation .
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Sigma-1 receptor modulator-1 is a sigma-1 receptor modulator and acetylcholinesterase (AChE) inhibitor. Sigma-1 receptor modulator-1 binds to sigma-1 receptors in guinea pigs with a Ki of 1.8 nM. Sigma-1 receptor modulator-1 modulates chaperone proteins, restores calcium homeostasis, and controls ROS production. Sigma-1 receptor modulator-1 inhibits AChE activity and scavenges free radicals. Sigma-1 receptor modulator-1 can be used for research on neurodegenerative diseases .
Cat. No.: HY-182710
CAS No.: 1081317-31-8
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DA-0218 is a Nav1.7 inhibitor. DA-0218 exerts state-dependent inhibitory effects. DA-0218 alleviates formalin-induced inflammatory pain behavior and Paclitaxel-induced mechanical hyperalgesia in mice. DA-0218 inhibits Histamine-induced acute pruritus and lymphoma-induced chronic pruritus in mice. DA-0218 can be used in research related to inflammatory pain, neuropathic pain, acute pruritus and chronic pruritus .
Cat. No.: HY-186188
CAS No.: 202815-29-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
