189 Results for "

DR

" in MedChemExpress (MCE) Product Catalog:
Products (189)

189 Results for "DR" in MCE Product Catalog:

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Cat. No.: HY-P8F045L
Synonyms: HLA-DR,HLA-DR-PC Blue,L243

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F045D
Synonyms: HLA-DR,HLA-DR-PE-Cy7,L243

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F045E
Synonyms: HLA-DR,HLA-DR-PE-CF596,L243

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F045J
Synonyms: HLA-DR,HLA-DR-APC-Cy7,L243

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P87245
Synonyms: DR 4 antibody

Host:  

Rabbit

Application:  

WB, IHC-P, FC

Reactivity:  

Human

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Cat. No.: HY-P8F045G
Synonyms: HLA-DR,HLA-DR-PerCP-Cy5.5,L243

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P992473

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

TAS266 is a tetrameric nanobody agonist targeting DR5. TAS266 selectively induces cancer cell death. TAS266 triggers sustained tumor regression in xenograft models and also elicits immunogenic responses including antibody binding. TAS266 exhibits superior anti-tumor efficacy compared with traditional DR5-targeting strategies. TAS266 can be used in research related to pancreatic cancer and advanced solid tumors .
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Cat. No.: HY-P992340

Research Areas:  

Cancer

CTB006 is a monoclonal antibody targeting a humanized chimeric recombinant anti-DR5. CTB006 specifically binds to and activates DR5, thereby inducing tumor cell apoptosis, inhibiting tumor growth and reducing tumor drug resistance. 177Lu-radiolabeled CTB006 can deliver targeted radiotherapy to tumor cells; while 89Zr- or 177Lu-labeled CTB006 can serve as a PET/CT imaging agent for detecting DR5 expression levels in preclinical tumor models and screening cancers with DR5 overexpression. CTB006 can be applied to research related to gastrointestinal cancer, colorectal cancer and other solid tumors .
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Cat. No.: HY-121200
CAS No.: 25279-67-8
Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity .
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Cat. No.: HY-183390
CAS No.: 136565-26-9
Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor. By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1, c-myc, and survivin; it also upregulates DR4/DR5 and downregulates Bcl-2, thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK, and can inactivate HSV-1. It shows synergistic antiviral effects when combined with Acyclovir (HY-17422) or Ganciclovir (HY-13637), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer, cervical cancer, glioblastoma, and digestive system cancers .
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Cat. No.: HY-P89757
Synonyms: Protein DR1, Down-regulator of transcription 1, Negative cofactor 2-beta, TATA-binding protein-associated phosphoprotein, NC2-beta, DR1

Host:  

Mouse

Application:  

WB, ICC/IF, IF-Tissue, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-181955
MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. MS1129 upregulates TRAIL, DR4 and DR5 proteins, downregulates the decoy receptor DcR2, and activates TRAIL-dependent apoptosis via the HIF-1/2 and Caspase-10 pathways. MS1129 is applicable to the research of VHL-deficient clear cell renal cell carcinoma .
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Cat. No.: HY-P85015
Synonyms: DASS-397D15.1 antibody; DR alpha chain antibody; DR alpha chain precursor antibody; DRA_HUMAN antibody; DRB1 antibody; DRB4 antibody; FLJ51114 antibody; Histocompatibility antigen HLA DR alpha antibody; Histocompatibility antigen HLA-DR alpha antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR alpha chain antibody; HLA DR1B antibody; HLA DR3B antibody; HLA DRA antibody; HLA DRA1 antibody; HLA DRB1 antibody; HLA DRB3 antibody; HLA DRB4 antibody; HLA DRB5 antibody; HLA-DR histocompatibility type antibody; HLA-DRA antibody; HLADR4B antibody; HLADRA1 antibody; HLADRB antibody; Major histocompatibility complex class II DR alpha antibody; Major histocompatibility complex class II DR beta 1 antibody; Major histocompatibility complex class II DR beta 3 antibody; Major histocompatibility complex class II DR beta 4 antibody; Major histocompatibility complex class II DR beta 5 antibody; MGC117330 antibody; MHC cell surface glycoprotein antibody; MHC class II antigen DRA antibody; MHC II antibody; MLRW antibody; OTTHUMP00000029406 antibody; OTTHUMP00000029407 antibody; HLA-DRA nanobody;

Host:  

Mouse

Application:  

ELISA

Reactivity:  

Human

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Cat. No.: HY-P811636
Synonyms: DR1-associated corepressor, DR1-associated protein 1, Negative cofactor 2-alpha, NC2-alpha, DRAP1

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P87404

Host:  

Rabbit

Application:  

WB, ICC/IF, FC

Reactivity:  

Human

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Cat. No.: HY-P83916
Synonyms: MLRW; HLA-DRA1

Host:  

Mouse

Application:  

WB, ICC/IF, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-183402
CAS No.: 917813-60-6
Synonyms: GO-Y026
Research Areas:  

Cancer

FLLL12 (GO-Y026) is a curcumin analog anticancer agent. FLLL12 inhibits the phosphorylation of AKT, Bcl-2, Bid, EGFR, mTOR, FOXO1a, FOXO3a, STAT3, HER2/neu, as well as pancreatic AKT/STAT3; upregulates the expression of Bim and DR5; and activates PTPs. FLLL12 regulates downstream pathways, induces mitochondria-mediated and DR5-dependent extrinsic apoptosis, inhibits cancer cell viability, proliferation, anchorage-independent growth and migration, and exerts a synergistic effect with Doxorubicin (HY-15142A). FLLL12 can be used in research related to head and neck squamous cell carcinoma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, colon cancer and colorectal cancer .
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Cat. No.: HY-P83916A
Synonyms: MLRW; HLA-DRA1

Host:  

Mouse

Application:  

WB, ICC/IF, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P700707
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF25; Apoptosis-Mediating Receptor DR3; Prev. TNFRSF12; Protein WSL-1; LARD; Tumor Necrosis Factor Receptor Superfamily Member 25 Deletion Mutant; DDR3; Tumor Necrosis Factor Receptor Superfamily, Member 25; DR3; Death Domain Receptor 3 Soluble Form;
Species:  
Mouse
Source:  
HEK293
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