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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
97 Results for "
GSPT
" in MedChemExpress (MCE) Product Catalog:
Products (97)
97 Results for "GSPT" in MCE Product Catalog:
Cat. No.: HY-RS05868
Target:
Research Areas:
GSPT1 Human Pre-designed siRNA Set A contains three designed siRNAs for GSPT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05869
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GSPT2 Human Pre-designed siRNA Set A contains three designed siRNAs for GSPT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-143435
CAS No.: 329706-62-9
Research Areas:
AG6033 is a CRBN-dependent molecular glue degrader targeting GSPT1 (DC50 of 2.5 μM) and IKZF1. AG6033 induces degradation of GSPT1 via π-π stacking and hydrogen bonding with CRBN in a partially CRBN-dependent manner, decreases IKZF1 levels, and promotes degradation of CRBN substrates. AG6033 induces apoptosis in lung adenocarcinoma cells. AG6033 can be used for the research of lung cancer .
Cat. No.: HY-159622
CAS No.: 3024909-51-8
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Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl is a synthetic intermediate for molecular glue. Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used in synthesis GSPT1 degrader-9 (HY-159610) .
Cat. No.: HY-163938A
CAS No.: 3033871-15-4
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PROTAC erf3a Degrader-2 (Compound C59) is an orally active PROTAC erf3a Degrader. PROTAC erf3a Degrader-2 inhibits protein expression of SRD5A3 and GSPT1(eRF3a). PROTAC erf3a Degrader-2 inhibits cancer cell proliferation (eg: 22Rv1). PROTAC erf3a Degrader-2 can be used for research of prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer .
Cat. No.: HY-159623
CAS No.: 3024909-50-7
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Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl is a synthetic intermediate for molecular glues. Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize GSPT1 degrader-9 (HY-159610) .
Cat. No.: HY-159619
CAS No.: 3034310-18-1
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Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl is a PROTAC Linker. Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl can be used in the synthesis of PROTAC GSPT1 degrader-1 (HY-159609) .
Cat. No.: HY-W599025
CAS No.: 2914920-46-8
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5-Br-4-Cl-Pyrrolo-pyroxypyridine is a synthetic intermediate for molecular glues. 5-Br-4-Cl-Pyrrolo-pyroxypyridine can be used for synthesis GSPT1 degrader-9 (HY-159609) .
Cat. No.: HY-159620
CAS No.: 3034310-00-1
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Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl is an E3 Ligase Ligand-Linker Conjugate. Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize PROTAC GSPT1 degrader-1 (HY-159609) .
Cat. No.: HY-132862
CAS No.: 2711006-74-3
ZXH-4-137 is a CRBN PROTAC degrader. ZXH-4-137 brings CRBN and VHL E3 ligase into proximity, induces CRBN ubiquitination and proteasomal degradation, and exhibits high selectivity for CRBN. ZXH-4-137 blocks the degradation of CRBN-dependent target proteins such as GSPT1 and CDK9. ZXH-4-137 serves as a chemical knockdown tool compound for investigating CRBN-dependent biological processes .
Cat. No.: HY-177751
Research Areas:
GSPT1 degrader-12 is a selective molecular glue GSPT1 degrader. GSPT1 degrader-12 exhibits antiproliferative activity against cancer cells in a CRBN- and GSPT1-dependent manner. GSPT1 degrader-12 can be used for leukemia research .
Cat. No.: HY-188006
CAS No.: 3052938-18-5
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GSPT1 degrader-18 is a GSPT1 degrader that inhibits the proliferation of cancer cells. GSPT1 degrader-18 has weak ability to induce the formation of the GSPT1-CRBN/DDB1 ternary complex and belongs to a weak molecular glue. GSPT1 degrader-18 can be used in cancer-related research .
Cat. No.: HY-181084
CAS No.: 3039500-55-2
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PROTAC BCL6/GSPT1 Degrader-1 is a dual-target PROTAC degrader that targets BCL6 and GSPT1. PROTAC BCL6/GSPT1 Degrader-1 inhibits cell proliferation, promotes DNA damage, and induces cell cycle arrest and apoptosis in diffuse large B-cell lymphoma. PROTAC BCL6/GSPT1 Degrader-1 can be used for research on tumors such as lymphoma .
Cat. No.: HY-170407
CAS No.: 2250062-05-4
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mTOR/GSPT1 ligand-1 is a mTOR/GSPT1 ligand, which can be used for the synthesis of PROTACs, such as YB-3-17 (HY-170405) .
Cat. No.: HY-RS16544
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Gspt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gspt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22976
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Gspt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gspt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-130800R
CAS No.: 1860875-51-9
Synonyms: CC-90009 (Standard)
Research Areas:
Eragidomide (Standard) is the analytical standard of Eragidomide (HY-130800). This product is intended for research and analytical applications. Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4 CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation .
Cat. No.: HY-180836
Research Areas:
DIX-01 is a CRBN-recruiting molecular glue and cytotoxic agent targeting GSPT1, with an EC50 of 173 nM against human GSPT1. DIX-01 drives proteasomal degradation of GSPT1, IKZF1 and IKZF3, and induces cytotoxicity in cancer cells. DIX-01 inhibits tumor growth in a zebrafish xenograft model and can be used for research on acute myeloid leukemia and prostate cancer .
Cat. No.: HY-157830
CAS No.: 870120-63-1
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MDM2 ligand 6 is an MDM2 ligand that can be used in PROTAC synthesis-related research. MDM2 ligand 6 can serve as the target protein ligand moiety of the MDM2/GSPT1 PROTAC degrader WB156 (HY-174266) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
